Project Grant R01MH140962
- This $136,113 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research on the neural mechanisms underlying the co-occurrence of depression and anxiety in adolescents. The research aims to use advanced network analysis techniques to identify disturbances in brain networks that are shared by emerging depression and anxiety, providing critical insights into the prevention and treatment of these mental...
- This federal Project Grant award of $734,220.00 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the impact of early life adversity on positive affect and its neural mechanisms in relation to depression risk. The project aims to: (1) determine if there is a reduction in the behavioral persistence or intensity of positive affect for youth exposed to adversity, (2) examine if individual...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Federal Grant Program titled "Mental Health Research Grants" (CFDA 93.242), provides $418,750.00 to Yale University to mechanistically uncover the neuroanatomical substrates of anxiety-related brain circuits. The research aims to improve the understanding and treatment of anxiety disorders, which affect 1 in 14 people worldwide. The 5-year project, beginning on February 1, 2025, will utilize...
- The U.S. National Institute of Mental Health (NIMH) awarded a $154,796 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Trustees of Princeton University to conduct research on understanding fear relapse and its relationship to anxiety. The key objectives of this 5-year project are to: 1) leverage latent cause inference modeling to quantify individual differences in the computational processes underlying spontaneous recovery of fear during extinction, 2)...
- This $742,576 Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) will support research to understand the brain networks involved in anxiety and how they are affected by dopamine fluctuations in Parkinson's disease (PD) patients. The study aims to determine if anxiety and depression have distinct neural correlates in PD using functional MRI methods. This will involve assessing PD patients with and without anxiety, as well as healthy...
- This Project Grant award of $782,279 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to better understand and treat avoidance behaviors associated with anxiety disorders. The research will use an interdisciplinary approach to combine neural and behavioral data to validate a novel computational model of avoidance, test differences in avoidance behavior in individuals with clinically impairing anxiety, and examine if the...
- The National Institute of Mental Health (NIMH) awarded a $147,486 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of Oregon on September 28, 2025. This longitudinal study examines the linkages between neighborhood environment, puberty, sleep quality, and trajectories of depression in adolescent girls. The research aims to 1) identify the direct effects of neighborhood factors on depression, 2) investigate the mediating/moderating role of pubertal...
- This federal Project Grant award of $545,759 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research to determine whether and how enhancing serotonin transmission in the mouse infralimbic medial prefrontal cortex during adolescence can suppress activity in somatostatin neurons and enhance fear extinction in adolescents and adults. This research aims to improve understanding of the serotonin-mediated...
- This federal Project Grant award of $185,552.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to examine the neurocognitive and social factors underlying suicide risk in adolescent girls. The key objectives are to investigate two forms of sustained neurocognitive responsivity to social threat that may disrupt social connectedness and increase suicidal thoughts and behaviors in this population. The research will...
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is focused on understanding the neural mechanisms governing the acquisition, extinction, and renewal of fear and anxiety responses within the hippocampal-amygdala circuit in humans. The $211,248 award will enable the University of California, Los Angeles (UCLA) to conduct research using intracranial recording and stimulation of the human...
This Project Grant award, valued at $782,547.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The purpose of the grant is to study the role of puberty in the development of corticostriatal circuitry and its impact on avoidance behavior in adolescents with anxiety disorders. The research aims to investigate how the rise in pubertal hormones affects reward processing and learning circuits in the brain, and how this relates to approach-avoidance behaviors and anxiety symptoms in anxious youth. The project will utilize functional MRI data, computational modeling, and behavioral assessments to elucidate these relationships, with the ultimate goal of improving understanding and treatment of anxiety disorders in adolescents. The grant was awarded on August 19, 2025, with a planned completion date of July 31, 2030. The research will be conducted by the University of Pittsburgh, a prominent public research university.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $782.5k | 8/18/25 |