Project Grant K08NS144507
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $595,208 to The Regents of the University of California, San Francisco on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This five-year Project Grant, which extends through March 31, 2031, funds collaborative research investigating the cellular and circuit-level mechanisms underlying cognitive dysfunction and...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a Project Grant of $128,358 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award was obligated on February 16, 2026, with a completion date of January 31, 2028. The research, to be conducted at the University of Michigan's Ann Arbor campus, investigates cholinergic brain...
- Federal Project Grant Summary The University of California, San Francisco received a $117,747 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded July 7, 2026, with completion targeted for June 30, 2028. This grant supports basic neuroscience research investigating the functional roles of basal ganglia and cerebellar inputs to the motor thalamus...
- Federal Project Grant Award Summary The University of Pennsylvania received a $243,750 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded February 11, 2026, with completion targeted for December 31, 2027. This award supports fundamental neuroscience research investigating sleep and wake regulation mechanisms in the murine hypothalamus through...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $238,356 to The Regents of the University of California, San Francisco on August 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This project grant funds research to map brain circuits controlling sympathetic and parasympathetic nervous system outflow during emotional states through direct intracranial...
- Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $548,368 to the University of California, Davis on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support a five-year project extending through January 31, 2031. This Project Grant funds research investigating slow-wave sleep enhancement as a therapeutic intervention to treat epilepsy and its associated comorbidities....
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $216,025 to The Regents of the University of California, San Francisco on February 13, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This five-year career development award supports Dr. Jessica Jimenez's research investigating neural circuit mechanisms underlying impaired memory consolidation following sleep loss. The...
- This $2,965,125 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) aims to determine how neuronal population dynamics during non-rapid-eye-movement sleep (NREMS) regulate cortical-striatal coupling and impact behavioral automaticity versus flexibility. The project, titled "ROLE OF COORDINATED MULTI-AREA REACTIVATIONS DURING TRANSITIONS BETWEEN AUTOMATIC AND FLEXIBLE BEHAVIORS", is funded under the 21st Century Cures Act - Brain Research...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Boston Children's Hospital a Project Grant of $711,952 effective May 2, 2026, through April 30, 2031, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports basic neuroscience research investigating how circadian rhythm regulation influences synaptic function and sleep/wake behavior. The research team will...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of California, Davis $129,261 on July 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular mechanisms underlying sleep disruption in Smith-Kingsmore Syndrome (SKS). The project, scheduled for completion by November 30, 2029, will develop Drosophila melanogaster (fruit fly) animal...
Federal Project Grant Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of California, San Francisco a $238,680 Project Grant (CFDA 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders) on July 15, 2026, with completion targeted for June 30, 2031. The research project, "Dissecting Neural Circuits Regulating Sleep Fragmentation in Parkinson's Disease," investigates the neural mechanisms underlying sleep disturbances in Parkinson's disease patients using electrophysiological techniques in a mouse model. The work will employ ex vivo brain slice electrophysiology and in vivo electrophysiologic recordings to examine how the pedunculopontine nucleus—a brain region linking motor and sleep circuitry—integrates inputs and responds to dopamine loss. The project delivers two primary research products: (1) characterization of how pedunculopontine nucleus neurons process basal ganglia inputs following dopamine depletion using brain slice electrophysiology, and (2) measurement of pedunculopontine nucleus neuron firing patterns across sleep-wake transitions in parkinsonian mice using in vivo recordings. Under the mentorship of Drs. Alexandra Nelson and Ying-Hui Fu, Principal Investigator Dr. Marcott will leverage her clinical experience in movement disorders and existing expertise in dopamine signaling to develop new competencies in measuring brain activity across arousal states. The anticipated outcome is foundational knowledge to inform the development of targeted therapies addressing sleep disturbances in Parkinson's disease patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $238.7k | 7/13/26 |