Project Grant R01AG098906
- Federal Grant Award Summary The National Institute on Aging awarded a $684,567 Project Grant to Massachusetts General Hospital (The General Hospital Corporation) for a four-year research initiative beginning March 1, 2026 and concluding December 31, 2029, under the Aging Research program (CFDA 93.866). The grant supports a resubmission methodology study designed to assess the utility of 64Copper-Fibrin-Binding-Probe-8 Positron Emission Tomography (64Cu-FBP8 PET) for in vivo detection and...
- Summary of Federal Project Grant Award The National Institute on Aging awarded $129,330 in Project Grant funding to Massachusetts General Hospital (The General Hospital Corporation) under the Aging Research program (CFDA 93.866) for the period June 15, 2025 through March 31, 2030. This award supports research addressing the critical challenge of early detection and accurate diagnosis of Alzheimer's Disease and Related Dementias (ADRD) through development of a machine learning-based prediction...
- Federal Project Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $487,574 Project Grant on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the role of reactive astrocytes in the propagation and clearance of tau pathology in Alzheimer's disease. The project, with a completion date of February 28, 2030, will deliver scientific research outputs aimed at understanding whether glial fibrillary acidic...
- Federal Grant Award Summary The National Institute on Aging awarded The University of Texas Southwestern Medical Center a $3.18 million Project Grant under the Aging Research program (CFDA 93.866) to investigate the spatial organization and conformational ensembles of alpha-synuclein amyloids within cellular environments. The research, which commenced August 13, 2025, and extends through July 31, 2029, aims to identify amyloid conformations and their abundances inside cells to enhance...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $1.58 million Project Grant on March 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research characterizing microvascular impairment in adults with elevated genetic risk for Alzheimer's disease. The research initiative, which extends through January 31, 2030, investigates the physiological mechanisms through which the apolipoprotein E-epsilon 4 (APOE-E4) allele—the...
- Federal Grant Award Summary Emory University received a $2.27 million Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective May 15, 2025, with completion targeted for January 31, 2030. The award funds the development of a novel positron emission tomography (PET) ligand targeting poly(ADP-ribose) polymerase-1 (PARP1) for imaging in Alzheimer's disease and related dementias. The primary deliverable is a brain-penetrant, PARP1-selective...
- Federal Grant Award Summary Massachusetts General Hospital (The General Hospital Corporation) received a $3.17 million Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 15, 2026 through February 14, 2030. The award funds development and evaluation of cell therapy approaches to treat Alzheimer's disease by restoring inhibitory neural circuit function. The research focuses on transplanting embryonic mouse medial ganglionic...
- Federal Grant Award Summary Einsenca Inc. received a $995,756 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective July 1, 2025 through June 30, 2026. The award funds a Phase 0 study to evaluate the in vivo characteristics of an 18F-EH301 myeloperoxidase (MPO)-targeting positron emission tomography (PET) imaging agent in healthy volunteers and early Alzheimer's disease (AD) patients. This research addresses a critical gap in...
- Federal Grant Award Summary The National Institute on Aging awarded a $441,612 Project Grant to Boston University Medical Campus effective May 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the relationship between modifiable lifestyle risk factors and digital cognitive markers in Alzheimer's disease progression. The research leverages the Framingham Heart Study's multi-generational cohort to develop and validate digital cognitive assessment methods—including digital pen...
- Federal Grant Award Summary The National Institute on Aging awarded The Leland Stanford Junior University a Project Grant of $165,888 under the Aging Research program (CFDA 93.866) effective August 15, 2025, with a completion date of May 31, 2030. The grant supports neuroimaging and genomics research investigating the glymphatic system—the brain's waste clearance mechanism—in Alzheimer's disease. The research team will develop and validate novel, non-invasive biomarkers for characterizing...
The National Institute on Aging awarded Massachusetts General Hospital a $677,276 Project Grant (CFDA 93.866: Aging Research) effective February 15, 2026, through January 31, 2031, to advance positron emission tomography (PET) imaging research of alpha-synuclein pathology in neurodegenerative diseases. The award funds the development and clinical evaluation of [11C]SY08, a novel PET imaging agent that selectively binds fibrillar alpha-synuclein aggregates. The primary deliverables include determining whether [11C]SY08 PET imaging can differentiate dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy from healthy controls and Alzheimer's disease patients, and correlating regional binding patterns to the expected topological distribution of pathologic changes and associated clinical features. The research builds upon completed first-in-human clinical trial data demonstrating increased brainstem and cortical binding in Parkinson's disease and dementia with Lewy bodies participants, with limited binding observed in multiple system atrophy participants. This project represents a continuation of translational research efforts to establish PET molecular imaging as a diagnostic tool for alpha-synuclein-associated neurodegenerative diseases, paralleling the clinical impact achieved through amyloid and tau PET imaging in Alzheimer's disease. The award enables Massachusetts General Hospital's Research Management Division to conduct clinical studies and biomarker validation work that will support future diagnostic applications and clinical trial development for the aging population affected by these progressive neurological conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $677.3k | 2/4/26 |