Project Grant RF1NS138787
- This $616,200 Project Grant was awarded on February 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to explore the influence of neuromelanin, a dark pigment, on dopaminergic neurons in Parkinson's disease. The project aims to develop a novel mouse model that accumulates neuromelanin in dopamine neurons to study the resulting...
- The $2,674,385 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research by Colorado State University (CSU) to investigate the structure-function relationship for alpha-synuclein (α-syn) protein strains and their impact on the clinical presentation of Lewy body dementia (LBD) and multiple system atrophy (MSA). The research aims to overcome...
- This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
- This Project Grant award from the National Institute on Aging's (NIA) Aging Research Federal Grant Program (CFDA 93.866) is funding a $109,595 project at the University of California, Davis to characterize a novel non-human primate model of Alzheimer's disease. The project aims to perform comprehensive microscopic analyses to determine the patterns of tau-based neuropathology, neuronal loss, synaptic health, and neural circuit functionality in the brains of rhesus macaques with progressive tau...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for Parkinson's disease (PD) and Alzheimer's disease related dementias (ADRD). The $793,535 award, with a project period from December 1, 2024 to November 30, 2029, will fund studies...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA Program 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will provide $2,280,379 to the Regents of the University of Michigan to develop novel nanobody-based agents that can target pathogenic alpha-synuclein to block its cell-to-cell transmission. The grant aims to characterize these nanobody-based agents and assess their in vitro and in...
- This $742,576 Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) will support research to understand the brain networks involved in anxiety and how they are affected by dopamine fluctuations in Parkinson's disease (PD) patients. The study aims to determine if anxiety and depression have distinct neural correlates in PD using functional MRI methods. This will involve assessing PD patients with and without anxiety, as well as healthy...
- This federal Project Grant award of $606,548.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new recording modality called "mesoscopic electrophysiology" for non-human primates. The goal is to create a system that combines the large field of view and spatial resolution of fMRI with the temporal resolution of...
- This Project Grant award of $414,191 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Drexel University investigating the relationship between structural variations in alpha-synuclein (α-syn) protein fibrils and the development of distinct neurodegenerative synucleinopathies such as Lewy body dementia, Parkinson's disease, and multiple system atrophy....
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
This Project Grant award of $3,064,072.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to establish a non-human primate (NHP) model of alpha-synuclein (αSyn) pathology and test the hypothesis that αSyn pathology in the amygdala affects the regulation of anxiety and mood. The key objectives are to assess time-dependent changes in anxiety-, depression-, and motor-related behaviors, as well as associated neural correlates, in rhesus macaques overexpressing αSyn in the amygdala or substantia nigra pars compacta (SNpc). The research also aims to characterize the αSyn burden and distribution induced by targeted overexpression in these brain regions. The award was made on Aug 4, 2025 with an ultimate completion date of Jul 31, 2029, and will be conducted by researchers at the University of Wisconsin-Madison.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 8/1/25 |