Project Grant R21EY038404
- Federal Project Grant Summary The National Eye Institute (NEI) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a Project Grant totaling $1,141,121 (awarded September 1, 2025, with completion targeted for April 30, 2030) under the Vision Research program (CFDA 93.867). This award funds research investigating the role of melanopsin in photoreceptor outer segment renewal, a fundamental homeostatic mechanism essential for maintaining lifelong photoreceptor...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded Indiana University Indianapolis a Project Grant totaling $435,875 under the Vision Research program (CFDA 93.867) to investigate the relationship between the orexinergic system and circadian rhythm disruption (CRD). The research addresses how excessive exposure to artificial blue light from smart devices disrupts circadian rhythms and causes retinal dysfunction, with particular focus on young adults who experience twice the...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $435,052 Vision Research (CFDA 93.867) Project Grant to the University of Massachusetts Boston for the period July 1, 2025 through June 30, 2029. This research project will investigate the molecular and genetic mechanisms that control photoreceptor subtype specification for color vision in the fruit fly (Drosophila melanogaster) retina as a model system. The research will identify conserved transcription factors and...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant totaling $248,737 under the Vision Research program (CFDA 93.867) with an award date of June 1, 2026, and completion date of May 31, 2029. The Research Foundation For The State University Of New York, serving as the fiscal agent, will conduct research to decipher the role of mitochondrial and autophagy dysfunction in regulating inflammatory processes during dry age-related macular degeneration (AMD)...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded the University of Rochester a $1.31 million Project Grant under the Vision Research program (CFDA 93.867) effective July 1, 2025, through April 30, 2029, to investigate the pathogenic role of secretory phospholipase A2-IIA (PLA2G2A/sPLA2-IIA) in age-related macular degeneration (AMD). AMD is a leading cause of adult blindness with limited treatment options, presenting in two forms: geographic atrophy (dry form) and choroidal...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Grant Award Summary The National Eye Institute (NEI) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a Project Grant totaling $615,928 under the Vision Research program (CFDA 93.867) to conduct mechanobiology research on Bruch's membrane during aging and its implications for age-related macular degeneration (AMD). The four-year project, which commenced April 15, 2026 and concludes March 31, 2030, will generate spatial and temporal protein composition maps...
- Federal Grant Award Summary Northwestern University received a $132,003 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded May 5, 2026, with completion scheduled for March 31, 2028. The project, titled "Retinal Modulation of Basal Forebrain Circuits," funds fundamental neuroscience research to identify the mechanisms by which light acutely influences neural circuits and behavior. The research will elucidate how retinal...
- Federal Project Grant Award Summary Wayne State University received a $385,000 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective August 1, 2025 through July 31, 2029. The grant supports research investigating genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research utilizes zebrafish models to compare transcriptional, cellular, and functional changes occurring during chronic and...
Award Title: A Molecular Mechanism of Blue Light Toxicity Impacting the Visual Cycle Funding Agency: National Eye Institute (NEI) This Project Grant funds fundamental research investigating the molecular mechanisms by which blue light exposure induces retinal degeneration through a photochemical pathway involving the phototoxic byproduct A2E (N-retinylidene-N-retinyl ethanolamine). The research will generate scientific findings on blue light-catalyzed lipid peroxidation pathways and characterize epoxyketooctadecenoic acids (EKODEs) as oxidation byproducts capable of inhibiting lecithin retinol acyltransferase (LRAT), a critical enzyme in the visual cycle. Research products include molecular characterization of wavelength-dependent photoactivation mechanisms using liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods, proteomic mapping of EKODE-protein adducts in vitro and in vivo, and empirical findings establishing the mechanistic link between blue light exposure, EKODE formation, and photoreceptor degeneration. The project aims to address a critical knowledge gap in understanding blue light-induced retinal damage at the molecular level, with findings expected to inform therapeutic development strategies for vision loss prevention. Research will be conducted at Case Western Reserve University's facilities in Cleveland, Ohio, utilizing bovine eyecup models and established biochemical methodologies to validate the proposed EKODE-LRAT inhibition pathway.Federal Grant Award Summary
Federal Grant Program: Vision Research (CFDA 93.867)
Award Amount: $384,422
Award Period: June 1, 2026 – May 31, 2028
Recipient: Case Western Reserve University, Cleveland, OH
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $384.4k | 6/5/26 |