This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional changes that occur during chronic and acute photoreceptor damage in zebrafish models. The goal is to better understand neuroprotection mechanisms and Müller glia reactivity to neuronal damage, which could inform new approaches to treating vision-related conditions and diseases. The research leverages state-of-the-art bioinformatic techniques, cell sorting, pharmacological treatments, and visual function assessments to address these critical knowledge gaps.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $385.0k | 7/23/25 |