Project Grant R01EY036459

Award Date 7/1/25
Completion Date 6/30/29
Dollars Obligated $435K
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), supports research to characterize the composition and function of Optix-cofactor transcription complexes in the development of the Drosophila (fly) visual system. The $448,250 award, effective May 1, 2025 through April 30, 2027, aims to identify the specific Optix-cofactor complexes, define their properties, and generate Optix protein variants to demonstrate the...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...
This Project Grant award of $947,974 from the National Eye Institute (CFDA 93.867 Vision Research) supports research to understand how the retina and visual system adapt to dynamic changes in light intensity encountered in natural environments. The overarching goal is to examine retinal coding under these naturalistic conditions to determine how diverse adaptation mechanisms across photoreceptors, interneurons, and retinal ganglion cells collectively shape visual signaling to the brain. The...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), will fund research to understand the genetic causes of inherited retinal degenerations (IRDs), a group of rare blinding diseases. The $1,369,782 award to the Massachusetts Eye and Ear Infirmary will support two key research aims: Developing a high-throughput splicing assay to identify rare coding and non-coding variants that lead to splicing defects and contribute to the...
This Project Grant award of $517,600 from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) supports research to investigate the interaction between visual signals that evoke eye fixation and optokinetic reflex in the retina. The research, to be conducted at Washington University, aims to gain new fundamental knowledge about the neural circuits and computational logic underlying the competition between central and peripheral vision. Using larval...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at Drexel University to characterize visual feature encoding in two types of visual projection neurons, LPLC1 and LPLC2, in the Drosophila visual system. The $104,012 award, spanning December 2024 to December 2026, aims to map the receptive fields of these neurons, investigate the mechanisms of inhibition that shape their feature and receptive field selectivity, and model how...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $1,241,223 to the University of Pittsburgh to conduct research on the genetic and epigenetic circuits underlying retinal transcription programs and how perturbations in the retinal core regulatory networks lead to congenital vision disorders. The key objectives are to: 1) Use mouse models to dissect the molecular, cellular, and genomic effects of genetic mutations on retinal development; 2)...
The National Eye Institute (NEI) has awarded a $592,457 Project Grant (CFDA 93.867 - Vision Research) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to characterize the response features of intrinsically photosensitive retinal ganglion cells (ipRGCs) and understand how they shape signals sent from ipRGCs to the brain. The award period is from September 30, 2024 to August 31, 2029. The research aims to strengthen the basic understanding of ipRGCs, sensory...
This is a Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), in the amount of $249,000.00. The grant will fund research to investigate the molecular mechanisms that regulate the expression of phototransduction genes in mammalian rod photoreceptors. The research aims to elucidate how transcriptional elongation and mRNA processing are coupled to enhance the efficiency and accuracy of mRNA maturation, and how defects in these...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to investigate the neural mechanisms of sensory encoding after photoreceptor degeneration. The $237,588 award, which runs from June 1, 2025 to December 31, 2027, will leverage the cone-DTR mouse model to study how cone degeneration impacts noise correlations and visual function in on-direction selective ganglion cells. The research aims to improve understanding of the role of noise...

This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to understand the molecular mechanisms that specify different subtypes of photoreceptor neurons for color vision. The $435,052 award to the University of Massachusetts Boston aims to elucidate how conserved transcription factors and cis-regulatory mechanisms control the spatially precise expression of opsins in specific photoreceptor neuron subtypes. The research will focus on deciphering the regulatory logic underlying the blue- vs. green-sensitive photoreceptor fate decision in the Drosophila retina, which involves conserved factors associated with human retinopathies. The 4-year project seeks to provide fundamental insights into photoreceptor diversity and opsin expression regulation, which could inform strategies for treating vision disorders.

Generated 8/5/25, 6:11 AM