Project Grant R21DE035282
- This federal Project Grant award of $239,405.00, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the neural circuit mechanisms of peripheral nerve stimulation for the treatment of trigeminal neuropathic pain. The research aims to elucidate how peripheral nerve stimulation activates the thalamic reticular nucleus, a key brain region involved in regulating...
- This federal Project Grant award for $1 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to establish generalizable genome editing strategies that could be broadly applicable to treat hundreds of rare disease-causing genetic variants. The proposed work will address rare loss-of-function alleles and rare gain-of-function alleles, and will be studied in the context of...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $423,500.00 to Nova Southeastern University, Inc. to develop a humanized mouse model of periodontitis. The goal is to investigate the potential pathogenic role of the protein Semaphorin 4D expressed by human osteoclasts in the progression of periodontal disease. This advanced mouse model will allow researchers to...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to establish a novel zebrafish model of syndromic craniosynostosis. The $313,000 award to Emory University will enable comprehensive phenotypic, mechanistic, and genetic analyses of the craniosynostosis mutant zebrafish to better understand the underlying pathological mechanisms. The research aims to identify...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $688,679 to the University of Southern California (USC) to develop innovative technology for comprehensively mapping the transcriptomes and lineage histories of all cell types in the vertebrate face. The project aims to define the diversity of mesenchymal progenitors, lineage relationships, and variations across...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $273,009 Project Grant to Virginia Commonwealth University (VCU) to characterize a conserved streptococcal membrane protein affecting manganese utilization. The project aims to determine the crystal structure and functional role of this membrane protein, hypothesized to be an acyltransferase that incorporates polyunsaturated fatty acids...
- This $165,000 Project Grant, awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research conducted by the Massachusetts General Hospital to map drug-sensitive gene expression profiles to spatial patterns of heterogeneity in a mouse model of schwannoma. The research aims to transform healthcare for military service members, veterans, and the broader public by advancing scientific understanding and developing potential...
- This federal Project Grant award of $600,029.00, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the mechanisms by which dysregulation of the Ras/MAPK signaling pathway leads to craniofacial and dental abnormalities in Rasopathy syndromes. The awardee, Cedars-Sinai Medical Center, will use a combination of comparative morphometrics, transcriptomic, proteomic, and...
- This federal Project Grant award, valued at $453,750.00 and effective September 1, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research program led by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to advance the understanding of perioperative neurocognitive disorders (PND) and their association with disruptions in...
- This Project Grant award, with a total funding of $222,211, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The award supports research to understand how the chromatin modifiers PRDM3 and PRDM16 epigenetically control gene expression during craniofacial development. The project aims to define the molecular mechanisms regulating Wnt/β-catenin signaling in chondrocytes, identify...
This Project Grant award was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The $433,657 award supports the development of a novel rodent model of hemifacial spasm (HFS), a chronic neuromuscular disorder characterized by involuntary facial muscle contractions. The project aims to closely replicate the clinical manifestations of HFS by inducing demyelination of the facial nerve roots in mice using lysophosphatidic acid (LPA). Through this model, the research team at The General Hospital Corporation, doing business as Massachusetts General Hospital, seeks to advance the understanding of HFS pathophysiology and explore potential therapeutic interventions. The award commenced on August 11, 2025, and is expected to be completed by August 10, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.7k | 8/11/25 |