This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $446,875 to support research on the role of a novel G protein-coupled receptor, MRGPRX2, in the development of periodontal disease. The funded research aims to develop two humanized mouse models to study the contribution of MRGPRX2-expressing mast cells to Porphyromonas gingivalis-induced and ligature-induced...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $304,019.00 to Panorama Research Incorporated to identify and evaluate a panel of human anti-human OC-STAMP monoclonal antibodies. The goal is to develop a novel therapeutic to slow or halt the loss of alveolar bone and teeth in severe periodontitis. This Phase 1 project will utilize a ligature-induced periodontitis model...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical University of South Carolina. The grant, titled "CD38 Signaling in Aging-Associated Immune Responses Induced by Oral Pathogens," aims to define how oral pathogens affect aging-associated immune responses and determine if inhibition of the CD38 enzyme can alleviate inflammatory bone loss and...
This Project Grant award, totaling $101,356.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award aims to investigate the role of the mechanosensitive receptor PIEZO1 in mediating the formation of specialized "type H" blood vessels in the alveolar bone during periodontitis. Specifically, the research will: 1) Demonstrate that stimulation of PIEZO1 on endothelial cells can...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $381,216 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) from June 1, 2025 to March 31, 2030. The award will support research to investigate the role of the enzyme CD73 in regulating inflammation and bone loss associated with periodontal disease. Specifically, the project...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under its Oral Diseases and Disorders Research program (CFDA 93.121) provides $434,746 to Nova Southeastern University, Inc. to investigate the impact of diabetes-induced hyperglycemia on the development of peri-implantitis, a common complication following dental implant placement. The project aims to elucidate the mechanisms by which hyperglycemia leads to changes in the oral microbiome and promotes...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $588,952 to the University of Missouri System to develop a bio-inspired scaffold (PeroPatch) for regenerating Sharpey's fibers and periodontal tissues. The project aims to integrate crucial biophysical and biochemical cues into a matrix to guide periodontal ligament stem cell migration, growth, and formation of...
This Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to advance fundamental knowledge about periodontal tissue regeneration and stem cell regulation to improve predictable periodontal tissue regeneration. The $557,606 award to President and Fellows of Harvard College, doing business as Harvard Medical School, will fund research to: 1) characterize the properties of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $656,315 to Temple University to study the impact of cyclic strain on the pathogenesis of oral microbes, particularly Candida albicans and denture-related microbiota. The goal is to mechanistically understand how biomaterial cyclic strain, driven by chewing forces, can influence the virulence and dysbiosis of oral...
This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...