This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $600,029 to the Cedars-Sinai Medical Center to conduct research on the mechanisms by which dysregulation of the Ras/MAPK signaling pathway leads to craniofacial and dental malformations, a key feature of Rasopathy syndromes. The research aims to elucidate the cellular and molecular mechanisms underlying dental defects, enamel malformations, and variations in facial shape in these disorders, through a combination of comparative morphometrics in human patients, transcriptomic and proteomic analyses, and functional studies in mouse models and human patient-derived induced pluripotent stem cells. The findings are expected to improve early diagnosis and inform the development of therapeutic interventions for these birth defects. The project will be performed at Cedars-Sinai Medical Center and is scheduled for completion by February 2030.
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