This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the federal Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,029,581 to Virginia Commonwealth University (VCU) to conduct research on the two-component signaling systems of the oral bacterium Treponema denticola. The research aims to elucidate how T. denticola's sensory systems enable it to thrive in the diseased periodontal environment and contribute to periodontitis...
This $504,324 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will fund a research project led by Virginia Commonwealth University (VCU) to investigate the glycome (carbohydrate composition and structure) of the oral pathobiont Treponema denticola. The key objectives are to: 1) delineate the chemical composition, glycosidic linkages, and genetic determinants of sulfated...
This $232,500 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to explore the role of arginine phosphorylation in the physiology and pathogenesis of the dental pathogen Streptococcus mutans. The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) will conduct this two-year research project focused on understanding the function of this novel...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $745,966 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Oregon Health & Science University (OHSU) to investigate the role of a novel biosynthetic gene cluster (BGC) in the virulence and survival of Streptococcus mutans, the primary bacterium associated with severe early childhood tooth decay. The research aims to characterize how this BL-BGC impacts S. mutans' key virulence...
This $505,530 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) Federal Grant Program, supports research by the University of Florida on functional amyloid formation in the oral bacterium Streptococcus mutans. The project aims to explore the relationships between S. mutans amyloid-forming proteins and DNA configuration within adherent and detaching biofilms, determine the impact of membrane...
This Project Grant award of $163,411 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program supports research by The Ohio State University to investigate the interactions between health-associated and disease-associated oral bacteria in dental biofilms. The research aims to elucidate how these microbes partition nutritional niches and modify carbohydrate utilization preferences, with the long-term goal of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $226,500.00 to The Medical University of South Carolina to conduct research on the role of CD38 signaling in aging-associated immune responses induced by oral bacterial pathogens. The goal is to determine if inhibiting CD38, an inflammatory marker, can attenuate periodontal inflammatory bone loss and alleviate...
This $241,500 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, aims to identify diffusible small molecules that regulate the replication of the bacterial pathogen Porphyromonas gingivalis (P. gingivalis). The research seeks to determine the identity of growth-promoting cues produced by different strains of P. gingivalis and the bacterium Veillonella parvula that can...
The University of Alabama at Birmingham (UAB) received a $470,279 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The five-year grant, running from March 2025 to February 2030, will fund research to identify and characterize the role of bacterial oxidative stress responses in influencing the ecology and pathogenicity of oral Streptococcus species. The project aims to gain a...
This $656,315 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The overarching goal is to mechanistically study the effect of biomaterial cyclic strain on the pathogenesis of oral microbes, focusing on the fungal strain Candida albicans and denture-related microbiota. The research will use common denture materials (Aim 1), hard oral mucosa (Aim 2), and an animal model (Aim 3)...