This $453,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the genetic and cellular mechanisms underlying craniosynostosis, a common craniofacial birth defect. The research team at Boston University Medical Campus will use a zebrafish model to study the role of the ERF transcription factor in normal skull development and how its reduction...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
This National Institute of Dental and Craniofacial Research (NIDCR) Project Grant award under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $320,053 to the University of Southern California (USC) to conduct comprehensive research on the craniofacial skeleton and connective tissue development. The 8-year project will utilize advanced techniques in spatial transcriptomics and mouse genetics to identify genes and pathways regulating the assembly of the craniofacial...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $619,304.36 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on mapping and predicting the effects of transcription factor dosage on craniofacial morphology and disease. The project aims to develop tools to precisely modulate the dosage of craniofacial transcription factors in...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $606,296 project grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Missouri System on May 1, 2025. The grant supports a 5-year research project to develop state-of-the-art, three-dimensional growth models of the craniofacial complex using advanced cone-beam computed tomography (CBCT) imaging. The goal is to create new growth standards that incorporate the three-dimensional nature of the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $600,029 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Cedars-Sinai Medical Center. The grant, which runs from March 10, 2025 to February 28, 2030, supports research to elucidate the molecular and cellular mechanisms by which Ras/MAPK signaling dysregulation causes abnormal enamel formation and craniofacial development. The research aims to determine how Ras signaling disruption...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $302,318 Project Grant under the Oral Diseases and Disorders Research Program (CFDA 93.121) to Rutgers, The State University. The grant will fund research to investigate the effects of skull malformations and intracranial hypertension on the glymphatic and meningeal lymphatic systems in craniosynostosis. Key aims include testing if impaired glymphatic (cerebrospinal fluid) influx and efflux impedes the clearance of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $646,212 to support research on the role of primary cilia and C2CD3 in craniofacial skeletogenesis. The research aims to determine how mutations in the C2CD3 gene, which cause the human ciliopathy Oral-Facial-Digital Syndrome 14 (OFD14), impact skeletal differentiation, the association between the centriole and actin...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Program (CFDA 93.121), provides $1,867,823.00 to Cincinnati Children's Hospital Medical Center to study the genomic and developmental mechanisms underlying Six2-related frontonasal dysplasia, a congenital craniofacial disorder. The research aims to unravel how structural variations in the genome can disrupt the local organization of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $521,209.45 to The Research Foundation for the State University of New York (RF SUNY) to delineate the role of the transcriptional repressor ZEB2 in human neural crest cell formation and craniofacial pathology. The research aims to examine ZEB2's modular functionality in regulating TGFβ signaling during normal human...