Project Grant R00DE031349
- This Project Grant award, totaling $493,458, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The grant aims to investigate the role of ARID1 proteins in regulating cranial neural crest cell (CNCC) development, which is critical for proper craniofacial formation. The project will examine how ARID1A and ARID1B, subunits of the chromatin remodeling complex BAF, dynamically...
- This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
- This federal Project Grant award of $315,289.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The award supports research to investigate the role of the SIX1 transcription factor in neural crest cell fate determination within the mouse mandibular arch. The project aims to identify changes in cell populations and the impact of SIX1 variants linked to Branchio-Oto-Renal syndrome on...
- This federal Project Grant award of $1,608,956.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to generate a single-cell multimodal atlas of human craniofacial development and conduct evolution-driven computational and experimental studies of enhancers involved in human midface development. This research is intended to improve understanding of the genetic...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $688,679 to the University of Southern California (USC) to develop innovative technology for comprehensively mapping the transcriptomes and lineage histories of all cell types in the vertebrate face. The project aims to define the diversity of mesenchymal progenitors, lineage relationships, and variations across...
- The University of North Carolina at Chapel Hill was awarded a $130,122 Project Grant by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research investigating the roles of the chromatin-modifying enzymes KMT2C and KMT2D in chondrocyte differentiation and endochondral ossification, which are critical processes for craniofacial and skeletal development. The project aims to utilize genomic...
- This federal Project Grant award of $600,029.00, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the mechanisms by which dysregulation of the Ras/MAPK signaling pathway leads to craniofacial and dental abnormalities in Rasopathy syndromes. The awardee, Cedars-Sinai Medical Center, will use a combination of comparative morphometrics, transcriptomic, proteomic, and...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (CFDA 93.121 - Oral Diseases and Disorders Research) provides $217,100 to the University of Illinois to support a training plan and research on the role of the NG2/CSPG4 proteoglycan in the healing of mandibular fractures. The research utilizes a preclinical murine model and transgenic knockout animals to study the molecular pathways controlling mandibular fracture resolution, with the goal of improving...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to establish a novel zebrafish model of syndromic craniosynostosis. The $313,000 award to Emory University will enable comprehensive phenotypic, mechanistic, and genetic analyses of the craniosynostosis mutant zebrafish to better understand the underlying pathological mechanisms. The research aims to identify...
- This $453,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the genetic and cellular mechanisms underlying craniosynostosis, a common craniofacial birth defect. The research team at Boston University Medical Campus will use a zebrafish model to study the role of the ERF transcription factor in normal skull development and how its reduction...
This Project Grant award, with a total funding of $222,211, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The award supports research to understand how the chromatin modifiers PRDM3 and PRDM16 epigenetically control gene expression during craniofacial development. The project aims to define the molecular mechanisms regulating Wnt/β-catenin signaling in chondrocytes, identify conserved functions of chondrocyte polarity and differentiation in the mammalian craniofacial complex, and assess the roles of PRDM3- and PRDM16-regulated Wnt/β-catenin enhancers in the craniofacial mesenchyme. This research, to be conducted at the University of New Mexico from May 1, 2025 to April 30, 2028, is expected to provide insights into how epigenetic modifiers control gene regulatory networks and signaling pathways critical for proper craniofacial development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $222.2k | 8/6/25 |