Role of circadian rhythms and sleep disorders in perioperative neurocognitive disorders trajectories
Active Project Grant Awarded Last action
- Award ID
- R35GM159961
- Recipient
-
The General Hospital Corporation UEI FLJ7DQKLL226
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $907,500
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 23% complete
- Place of performance
- Massachusetts, USA
Award details come from USAspending.gov.
Description
- Abstract
- Perioperative neurocognitive disorders (PND) pose a significant public health problem for patients, leading to detrimental consequences, including increased healthcare costs, functional disability, and long-term cognitive impairment. Understanding its pathogenesis is an area of active research, much of which is focused on the physiological impact of surgery and anesthesia on the central nervous system (CNS). Disruption of circadian rhythms and sleep interferes with biological processes integral to health and the CNS. We observed that patients with sleep disorders have injuries in multiple brain sites that are further exacerbated by surgery. We documented that surgery/anesthesia ignites the underlying brain lesions, leading to an attendant decrease in performance in several cognitive domains. Recent genetic studies point to shared links between sleep and brain health. Whether genetic variations of circadian rhythms and sleep affect PND remains unexamined. My research program will use a multifaceted approach to advance our understanding of perioperative cognitive trajectories, with the goals for the next five years to 1) implement a comprehensive, perioperative neurocognitive assessment program that is accessible to a diversity of populations; 2) gather, analyze, and characterize perioperative sleep/activity abnormalities; 3) identify genetic variants that might play a role in hastening the development of PND. My past and ongoing work incorporates new tools and models to harness and implement technological innovations to understand the mechanisms and risk factors involved in the origins and trajectories of PND. I am well-positioned to lead this research program, with a proven track record, within an excellent institutional environment, and with current and future collaborators positioned to contribute to this program with expertise in genetic studies and circadian phenotyping. Highlights of expected outcomes: 1) collection and analyses of high volumes of comprehensive cognitive data that will provide for the development of prehabilitation programs; 2) causal associations between perioperative sleep disorders and cognitive impairment that will initiate sleep optimization programs and novel therapeutic targets; 3) identification of genetic risk for PND; and 4) discovery of novel mechanisms, pathways, and interactions that may lead to the development of pharmacological interventions. The successful execution of this proposal will produce an innovative framework linking genetic variants with PND and lead to therapeutic strategies that will improve brain health for all populations. In line with the mission of the nigms, the goal of this proposal is to lay the research foundation for understanding the interconnected biological processes between PND and sleep, while advancing the diagnosis, treatment, and prevention of these intractable and devastating diseases. Effective prevention strategies for PND will improve the overall health, lifespan, and well-being of surgical patients and communities, help dampen the skyrocketing healthcare costs, and disrupt the cycle of disability and long-term care after surgery.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $453,750 | |
| Original award | $453,750 |
Quick answers
Who received award R35GM159961?
R35GM159961 was awarded to The General Hospital Corporation by National Institute of General Medical Sciences (National Institutes of Health) on September 1, 2025.
How much is award R35GM159961 worth?
$907,500 has been obligated on R35GM159961.
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