Project Grant R21AG100956
- Federal Grant Award Summary The University of Pittsburgh received a $3.1 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports biomedical research investigating the mechanistic relationship between persistent DNA damage-induced immune responses and aging. Specifically, the research examines how the cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes)...
- Federal Project Grant Award Summary The University of Pittsburgh received a $428,123 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) with an award date of February 1, 2026, and completion date of January 31, 2028. The grant funds research to identify and validate molecular targets for enhancing the regenerative capacity of aging chondrocytes and improving cartilage resilience. The research builds on preliminary findings identifying GATA Binding Protein...
- Federal Grant Award Summary The University of Pittsburgh received a $664,619 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This award supports comprehensive research into multiscale models of age-specific neurometabolic coupling, with a focus on understanding the relationship between neuronal activity and metabolic processes in late-onset Alzheimer's disease. The research deliverables...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Texas at Arlington $472,793 under the Aging Research program (CFDA 93.866) for a three-year project period running from September 1, 2025 through August 31, 2028. This Project Grant supports research to decouple reproductive aging from somatic aging by investigating the role of the mammalian target of rapamycin complex 2 (mTORC2) pathway, specifically the SGK-1 kinase component, in reproductive...
- Federal Grant Award Summary The University of Pittsburgh received a $801,268.00 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2030. This five-year research initiative focuses on developing real-world and innovative multimodal prediction and prevention approaches for postoperative mortality and multi-morbidity in elderly surgical patients. The project addresses a critical public health need by...
- Federal Project Grant Award Summary The University of Pittsburgh received a $2,003,400 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with completion targeted for August 31, 2029. This award supports research to characterize white matter injury in Alzheimer's disease (AD), a critical gap in understanding given that AD affects approximately 6.9 million Americans aged 65 and older, with projections reaching 13.8...
- Federal Project Grant Award Summary The University of Pittsburgh received a $667,664 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research program) awarded on August 15, 2025, with completion targeted for July 31, 2027. The grant funds research investigating how inhaled environmental stressors—specifically particulate matter (PM2.5), diesel exhaust particles (DEP), and cigarette smoke—impact two key mechanisms of lung aging: mitochondrial dysfunction and cellular...
- Federal Project Grant Award Summary Columbia University's Health Sciences Division received a $3.44M Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025 through August 31, 2029. This research initiative investigates the molecular mechanisms and genetic basis of human ovarian aging, addressing a significant gap in women's health research. The project employs advanced genomic sequencing techniques, including...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded Magee-Womens Research Institute and Foundation a $595,864 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of hyaluronan in primordial germ cell (PGC) development and ovarian reserve establishment. The award, issued August 15, 2025, with a completion date of May 31, 2030, supports basic...
- Federal Project Grant Award Summary The University of Virginia received a $522,167 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 1, 2025, with a completion date of May 31, 2030. This research project investigates the mechanisms of ribosomal DNA (rDNA) instability during aging, with a focus on understanding how DNA double-strand breaks and genomic instability contribute to cellular aging. The research examines the roles of FOB1 and its...
The University of Pittsburgh received a $453,785 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) for the period May 1, 2026 through April 30, 2028. This exploratory research project investigates the conserved functional role of TCERG1 (Transcription Elongation and RNA Capping Related Gene 1), a mammalian homolog of the C. elegans protein TCER-1, in regulating fertility and reproductive aging. The research will generate scientific knowledge regarding molecular mechanisms that coordinate the physiological trade-offs between reproductive investment, immune regulation, and somatic maintenance—processes that decline with age in both mammals and model organisms. The deliverables include experimental findings from two primary aims: (1) functional complementation studies assessing whether human or mouse TCERG1 can replace TCER-1 function in C. elegans models, and (2) mechanistic characterization of mouse TCERG1's role in fertility, ovarian reserve, and reproductive aging using knockout models. The research employs cross-species comparative approaches and leverages existing and newly generated transgenic mouse models to define TCERG1's function in alternative splicing of immune-related genes and its age-related decline in female oocytes. The project addresses a critical gap in understanding conserved molecular regulators of reproductive aging and age-related disease susceptibility relevant to the National Institute on Aging's mission to support research on aging processes and age-related conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $453.8k | 5/5/26 |