Project Grant RF1AG093116
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,208,503.00 to Cornell University to conduct research on the role of autophagy in cellular aging. The project, titled "System-wide and Mechanistic Deconvolution of Autophagy in Cellular Aging", aims to systematically investigate how different forms of autophagy influence cellular aging processes, with a focus on understanding how modulating selective autophagy pathways such...
- The National Institute on Aging awarded a $387,068 Project Grant under its Aging Research federal grant program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai (ISMMS) to investigate the mechanisms underlying cellular rejuvenation during oogenesis. The project aims to define the spatiotemporal dynamics of nuclear pore complex (NPC) turnover, determine the factors that promote NPC rejuvenation, and assess the biological relevance of these NPC rejuvenation pathways to oocyte...
- This $472,793 Project Grant was awarded by the National Institutes of Health (NIH) National Institute on Aging under the Aging Research federal grant program (CFDA 93.866) to the University of Texas at Arlington. The grant aims to develop an automated device to study reproductive aging in the C. elegans nematode model, with a focus on understanding how the nutrient-sensing mTORC2 pathway regulates reproductive senescence independently from somatic aging. The research will investigate the roles...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This $625,898 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop spatially-informed, cell-specific metabolic models of the ovary to identify novel biomarkers associated with the onset and duration of the menopause transition. The key products and services to be delivered include: Generation of spatially-informed, cell-specific, multicellular genome-scale metabolic models (GMMs) of the ovary using single-cell and spatial transcriptomics data...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- The federal Project Grant award R21AG086723 for $466,125.00 was granted by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine to characterize age-related changes in the testis stem cell niche. The key objectives are to: (1) identify genes differentially expressed in young and aged testis niche cells and those dependent on activin signaling, and (2) develop new tools to monitor activin and follistatin proteins and pathway activity in the fly...
- This Project Grant award of $3,304,237 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a 40-year longitudinal study examining the links between early life adversity, cumulative life stress, and cellular aging in midlife women and their offspring. The study aims to assess which aspects of life course stress, including childhood, midlife, and cumulative stress, are associated with accelerated cellular aging at age 50. The study will repeat assessments of cell aging...
- This $412,751 Project Grant, awarded on August 15, 2024 by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund research by The Trustees of Columbia University in the City of New York to study protein turnover alterations in the aging brain. The project aims to: (I) study the stoichiometry of the ribosome and proteasome; (II) measure changes in protein complex composition; (III) reveal how aging affects protein interaction state turnover; and (IV) address the effects of...
This federal Project Grant award of $3,445,585 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the molecular mechanisms and genetic factors underlying human ovarian aging. The research aims to advance scientific understanding of how ovarian aging proceeds and its connections to broader women's health outcomes. The award recipient, The Trustees of Columbia University in the City of New York, will utilize single-cell sequencing techniques to analyze changes in gene expression and chromatin accessibility in ovarian tissues from young and older women. This work builds on the university's preliminary findings that ovarian aging involves accelerated activation of conserved aging pathways across different cell types. The research has the potential to inform future interventions to delay ovarian aging and its negative health impacts on women. The award period runs from September 2025 through August 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.4m | 8/20/25 |