Project Grant R01AG085115
Award Date
6/1/25
Completion Date
5/31/30
Dollars Obligated
$801K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
The National Institute on Aging awarded a $2,356,117 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University to study the perioperative management of patients with Alzheimer's disease and related dementias (ADRD). The award will support the development of models to assess the risks facing surgical patients with ADRD and evaluate the impact of perioperative interventions, such as the use of anesthetic agents, on short-term and long-term outcomes. The research will...
This $3,284,161 Project Grant was awarded on September 15, 2024 by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The grant supports research at the University of California, San Francisco (UCSF) to investigate the role of interleukin-6 (IL-6) trans-signaling in increasing vulnerability to postoperative cognitive decline in aging and Alzheimer's disease populations. The research aims to elucidate the mechanisms by which upregulation of IL-6...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $1,744,358 will fund the development and validation of novel analytical methods to better understand longitudinal recovery outcomes for older adults with Alzheimer's disease and related dementias (ADRD) who have sustained hip fractures. The project aims to 1) identify unique patient characteristics associated with poor recovery, 2) develop joint modeling approaches to uncover shared...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $2,245,769 aims to develop an integrated brain state monitoring system for personalized anesthesia decision support to prevent postoperative delirium in elderly and at-risk patients. The project, awarded to Pascall Systems, Inc., a for-profit medical technology company, focuses on four key objectives: Establishing technical feasibility for integrating the company's FDA-cleared wireless EEG...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $299,893 to Pascall Systems, Inc. to develop a novel system that combines pre-operative cognitive assessment with Pascall's FDA-cleared wireless EEG technology for intraoperative monitoring. The goal is to enable personalized anesthesia care and effective monitoring of postoperative neurocognitive disorders (PNDs) in elderly surgical patients. The key products and services to be delivered...
This $243,000 federal Project Grant award, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), aims to address critical knowledge gaps in caring for older adults with inflammatory bowel disease (IBD). The key objectives are to: 1) develop and validate a model to predict which older adults with IBD will require disease-related surgery; 2) create a preoperative model to predict the risk of major adverse postoperative events, incorporating measures of...
Duke University has been awarded a $4,537,430 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, to support research under the Aging Research program (CFDA 93.866). The grant will fund a study from September 2022 to August 2025 to examine the role of cellular senescence on postoperative neuroinflammation. Specifically, the researchers will use a mouse model of orthopedic fracture to determine how senescent cell burden exacerbates systemic...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $308,000 to the University of Rochester to develop and pilot test a user-friendly shared decision-making (SDM) tool for surgeons. The tool will be specifically designed to improve communication in the SDM process for frail older adults considering major colorectal surgery. The project will utilize a Delphi process with clinical experts and patient representatives to adapt an existing SDM...
This federal Project Grant award from the National Institutes of Health (CFDA 93.279 - Drug Abuse and Addiction Research Programs) provides $1,105,489 to The Leland Stanford Junior University (Stanford University) to fund research aimed at reducing the risk of persistent postoperative opioid use and opioid use disorder among older adults undergoing inpatient surgery. The key products and services to be delivered under this 2-year grant include: Augmenting an existing dataset that links...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $161,500 to the University of Virginia to investigate whether changes in perineuronal nets (PNN), which are protective extracellular matrix structures around specialized neurons, contribute to the development of postoperative delirium in aged mice. The research aims to determine if a decrease in parvalbumin-positive neurons enmeshed with PNN and increased levels of certain chondroitin sulfate...