Project Grant R01AG092661
- This $4.49 million project grant from the National Institutes of Health's National Institute on Aging will fund research at The Washington University to investigate the relationship between amyloid plaque deposition, cellular metabolic dysfunction, and functional brain organization in Alzheimer's disease (AD) mice models. Over three years, the researchers will use multi-photon fluorescence lifetime imaging microscopy, multi-parametric photoacoustic microscopy, and wide-field optical imaging to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,230,150.00 in funding to the University of Kansas Center for Research Inc. to investigate the interplay between neuronal activity, synaptic abnormalities, and mitochondrial dysfunction in Alzheimer's disease. The research aims to determine whether modulating neural activity, synapses, or mitochondria could enhance neural plasticity in animal models of Alzheimer's. Through a combination of...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,001,700.00 to the University of Pittsburgh to investigate risk factors and consequences of white matter injury in brain regions affected by Alzheimer's disease (AD) pathology. The project leverages the university's novel "Unhealthy White Matter Connectivity" (UWMC) methodology to comprehensively characterize white matter injury in AD, with the goal of informing refinement of...
- The University of Pittsburgh was awarded a $794,978 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct research on the mechanisms by which socioeconomic disadvantage across the lifespan impacts cognitive function and decline in midlife. The research will longitudinally examine accelerated epigenetic aging as a biological mechanism connecting individual and community-level socioeconomic disadvantage to poorer cognitive function and greater cognitive...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
- The National Institute on Aging (NIA) awarded a $759,352 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to The University of Kentucky Research Foundation. The goal of this 5-year grant, awarded on May 15, 2025, is to understand how shifts in microglial (brain immune cell) metabolism impact the progression of Alzheimer's disease (AD) and whether targeting metabolic pathways can reduce AD-related pathology. The grant will investigate the role of lactate, a byproduct...
- This $3.61 million project grant from the National Institutes of Health's National Institute on Aging will fund research from July 2022 to June 2025 aimed at understanding and addressing neurovascular coupling dysfunction in Alzheimer's disease and Alzheimer's disease-related dementias. Specifically, the University of Colorado Denver will investigate the hypothesis that restoring neurovascular coupling can mitigate synaptic plasticity deterioration in the hippocampus and its behavioral...
- This $500,000 Project Grant was awarded on September 15, 2024 by the National Institute on Aging (CFDA 93.866 Aging Research program) to Neucyte Inc., a minority-owned small business specializing in advanced biomedical research and development. The funding will support the development of a miniaturized "mini-brain" microphysiological system (MPS) platform using Alzheimer's disease (AD) patient-derived cells. The goal is to create a scalable, reproducible in vitro brain model that can...
- The National Institute on Aging (NIA) awarded a $1,558,726 Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh. The grant, titled "MENOBRAIN: A Longitudinal Investigation of Menopause and Brain Health," will conduct a 5-year study to elucidate the brain and cognitive changes that occur during the perimenopause phase of the menopause transition, and the factors contributing to these changes. The study will recruit 224 women in the late...
The University of Pittsburgh has been awarded a $664,619 project grant by the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct comprehensive research on the relationship between neuronal activity and metabolic processes in the brain, particularly in the context of Alzheimer's disease. The key products and services to be delivered under this 5-year grant include: Modeling single-cell neurometabolic coupling using in vivo two-photon microscopy to investigate the astrocyte-neuronal lactate shuttle and quantify the relationship between red blood cell velocity, lactate levels, and neural activity in late-onset Alzheimer's disease mouse models. Establishing cortical network models of neuro-metabolic coupling through multispectral wide-field imaging to examine the role of oxidative phosphorylation in neuronal connectivity, validate computational models with experimental capillary obstructions, and assess sex-specific differences in mitochondrial function. Building a whole-brain theory of neuro-metabolic coupling using non-invasive brain imaging techniques to explore the impact of glucose and creatine metabolism on whole-brain functional connectivity, integrating data from animal models and human cohorts to predict excitation-inhibition balance patterns. The goal of this multifaceted research program is to comprehensively study the intricate relationship between neuronal activity and metabolic processes in the brain, with a focus on understanding the role of metabolic dysfunctions in Alzheimer's disease and other neurodegenerative conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $664.6k | 12/26/25 |