Project Grant R15AG089221
- This $2,991,725 Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research into the role of reactive oxygen species as modulators of lifespan and age-related diseases. The 4-year project, which commenced on September 1, 2025, aims to investigate a novel longevity paradigm in C. elegans that is triggered by early-life oxidative stress and mediated by changes in the epigenetic landscape. The research will examine the conserved mechanisms...
- This federal Project Grant award of $3,445,585 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the molecular mechanisms and genetic factors underlying human ovarian aging. The research aims to advance scientific understanding of how ovarian aging proceeds and its connections to broader women's health outcomes. The award recipient, The Trustees of Columbia University in the City of New York, will utilize single-cell sequencing techniques to...
- Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how aging produces ultrastructural alterations to neuronal autophagy, which is critical for maintaining neuronal homeostasis and function. The $429,000 award to the University of Texas Health Science Center at Houston will be used to accomplish two specific aims over the 2-year project period starting January 1, 2025: Compare the ultrastructural features of axonal autophagic...
- The National Institute on Aging awarded a $387,068 Project Grant under its Aging Research federal grant program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai (ISMMS) to investigate the mechanisms underlying cellular rejuvenation during oogenesis. The project aims to define the spatiotemporal dynamics of nuclear pore complex (NPC) turnover, determine the factors that promote NPC rejuvenation, and assess the biological relevance of these NPC rejuvenation pathways to oocyte...
- The federal Project Grant award R21AG086723 for $466,125.00 was granted by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine to characterize age-related changes in the testis stem cell niche. The key objectives are to: (1) identify genes differentially expressed in young and aged testis niche cells and those dependent on activin signaling, and (2) develop new tools to monitor activin and follistatin proteins and pathway activity in the fly...
- This $1,081,439 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) supports research to uncover the biochemical mechanisms behind cellular aging. The project, titled "TRACING THE COORDINATED CONTROL OF NAD+ HOMEOSTASIS", aims to create a comprehensive database and metabolic map of NAD+ biology throughout the lifespan. This research will investigate how NAD+ metabolism is maintained, regulated, and disrupted as cells age, with...
- The University of Southern California received a $126,042 project grant from the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), to investigate the role of mitochondrial proline catabolism, specifically the ALH-6 gene, in muscle-mitochondrial dynamics and their impact on health and longevity. This research builds upon previous studies in C. elegans that have linked ALH-6 mutations to premature aging, impaired muscle function, and mitochondrial...
- This $147,486 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to investigate the role of chaperone-mediated autophagy (CMA) in cellular senescence and its contribution to aging. The research aims to understand: 1) if CMA activity changes upon induction of senescence, 2) if CMA modulates senescence kinetics and by what mechanism(s), 3) if CMA is required for senescent cell clearance, and 4) if restoring CMA activity...
- This $333,116 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the impact of telomere dysfunction and natural aging on the intestinal stem cell niche. The goal is to examine how aging and acute telomere failure suppress stromal niche support for intestinal stem cells, contributing to intestinal phenotypes associated with aging and telomeropathies like dyskeratosis congenita. The research will utilize a novel mouse...
This $472,793 Project Grant was awarded by the National Institutes of Health (NIH) National Institute on Aging under the Aging Research federal grant program (CFDA 93.866) to the University of Texas at Arlington. The grant aims to develop an automated device to study reproductive aging in the C. elegans nematode model, with a focus on understanding how the nutrient-sensing mTORC2 pathway regulates reproductive senescence independently from somatic aging. The research will investigate the roles of autophagy, fat metabolism, and mitochondrial dynamics in driving reproductive decline, using the highly accessible and controllable C. elegans system. This work seeks to decouple the molecular underpinnings of reproductive aging from somatic aging, providing insights that could inform interventions to address age-related infertility and pregnancy loss in humans. The award period runs from September 2025 through August 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $472.8k | 8/26/25 |