Project Grant R01AG089953
- This federal Project Grant award of $3,101,237.00 was provided by the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, under the Aging Research federal grant program (CFDA 93.866). The funding supports a research project investigating the mechanisms linking persistent DNA damage to immune responses and hematopoietic stem and progenitor cell function in the context of aging and DNA repair deficiency. Key objectives of the project include: 1) elucidating...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- The National Institute on Aging (NIA), through the Aging Research Federal Grant Program (CFDA 93.866), awarded Rockefeller University a $196,460 project grant to conduct research on the structural and functional characterization of the mRNA export platform in Saccharomyces cerevisiae. The goal of this 18-month project is to understand the molecular determinants of mRNA export platform assembly and elucidate the mechanisms by which aging-associated mutations affect platform assembly and lead to...
- This $2,991,725 Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research into the role of reactive oxygen species as modulators of lifespan and age-related diseases. The 4-year project, which commenced on September 1, 2025, aims to investigate a novel longevity paradigm in C. elegans that is triggered by early-life oxidative stress and mediated by changes in the epigenetic landscape. The research will examine the conserved mechanisms...
- This $1,081,439 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) supports research to uncover the biochemical mechanisms behind cellular aging. The project, titled "TRACING THE COORDINATED CONTROL OF NAD+ HOMEOSTASIS", aims to create a comprehensive database and metabolic map of NAD+ biology throughout the lifespan. This research will investigate how NAD+ metabolism is maintained, regulated, and disrupted as cells age, with...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of Southern California to investigate methods for purging mammalian cells of deleterious mutations in the mitochondrial genome (mtDNA) that contribute to aging and age-related diseases. The research aims to develop new genetic and molecular biology tools, combined with advanced sequencing techniques, to selectively remove harmful mtDNA mutations from...
- This National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $412,500 to the Trustees of Boston University (Boston University Medical Campus) will fund research to investigate the "vicious cycle" between disruption of chromatin architecture, activation of retrotransposable elements (RTEs), and misexpression of CpG island-deficient genes during the aging process. The research aims to validate the mutual activation between chromatin architecture disruption and RTE...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,208,503.00 to Cornell University to conduct research on the role of autophagy in cellular aging. The project, titled "System-wide and Mechanistic Deconvolution of Autophagy in Cellular Aging", aims to systematically investigate how different forms of autophagy influence cellular aging processes, with a focus on understanding how modulating selective autophagy pathways such...
- This Project Grant award, valued at $647,866.00 and provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the epigenetic regulation of nuclear cGAS activity and its role in aging-related inflammation. The key objective is to understand how aging-related changes in histone acetylation patterns and associated chromatin-binding proteins, such as BRD4, activate the innate immune sensor cGAS and contribute to chronic...
This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques like whole-genome double-strand break mapping to study these processes in both yeast and human cell line models. The goal is to establish novel functions for these regulatory factors in maintaining rDNA copy number homeostasis and lifespan. The award period runs from August 1, 2025 through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $522.2k | 7/30/25 |