Project Grant RF1AG093995
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This Project Grant award, valued at $647,866.00 and provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the epigenetic regulation of nuclear cGAS activity and its role in aging-related inflammation. The key objective is to understand how aging-related changes in histone acetylation patterns and associated chromatin-binding proteins, such as BRD4, activate the innate immune sensor cGAS and contribute to chronic...
- This $333,116 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the impact of telomere dysfunction and natural aging on the intestinal stem cell niche. The goal is to examine how aging and acute telomere failure suppress stromal niche support for intestinal stem cells, contributing to intestinal phenotypes associated with aging and telomeropathies like dyskeratosis congenita. The research will utilize a novel mouse...
- The Minnesota Nathan Shock Center of Excellence on Genome Integrity and Aging was awarded a $1,270,502 Project Grant by the National Institute on Aging (CFDA 93.866 Aging Research) on June 17, 2025. The goal of this grant is to provide access to specialized cores that can accurately measure DNA damage, DNA damage response signaling, DNA repair activity, and age-associated epigenetic changes in genomic DNA. The Center will also provide access to murine and human cell and tissue models with...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $378,750 in funding to Saint Louis University to conduct research on the role of cytosolic DNA-induced sterile inflammation in driving cellular and organismal progeria/aging hallmarks. The key objectives are to: 1) define the non-canonical mode of STING stimulation upon progerin-induced accumulation of cytosolic DNA, 2) examine how STING, STAT1, and downstream interferon-stimulated genes like...
- This federal Project Grant award for $1,249,147.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant is a collaborative effort between Epicypher, Inc., a biotechnology company in Durham, North Carolina, and Dr. Nicolas Young of Baylor College of Medicine to develop a novel platform called AgingPTM for studying aging-associated combinatorial histone post-translational modifications (ACPTMs) in tissue. This platform is intended to...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $408,600.00 to Trustees of Tufts College, doing business as Tufts University School of Medicine, to conduct research on the role of cytosolic DNA sensing in regulating tissue-resident macrophage function and organismal longevity. The key objectives of this research project are to: 1) Ascertain the role of endogenous retroelements in shaping tissue-resident macrophage survival and...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $132,705 Project Grant under the Aging Research program (CFDA 93.866) to The Children's Hospital Corporation (doing business as Boston Children's Hospital). The award aims to conduct research on "Targeting Metabolic Vulnerabilities to Restore Balanced Hematopoiesis During Aging," with a project period from June 15, 2025 to May 31, 2027. The research will use single-cell...
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
This federal Project Grant award of $3,101,237.00 was provided by the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, under the Aging Research federal grant program (CFDA 93.866). The funding supports a research project investigating the mechanisms linking persistent DNA damage to immune responses and hematopoietic stem and progenitor cell function in the context of aging and DNA repair deficiency. Key objectives of the project include: 1) elucidating the role of the cGAS-STING pathway and the NLRP12 transcription factor in driving persistent DNA damage-induced immune responses, and 2) evaluating the functional implications of this pathway using a conditional NLRP12 mouse model. The project aims to provide new insights into how the immune system responds to persistent DNA damage during aging and disease, with potential implications for developing interventions to support hematopoietic stem cell function. The award commenced on September 1, 2025 and is scheduled for completion on August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 8/26/25 |