Project Grant R21AG093631
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $3.16 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 1, 2026, through May 31, 2030. The award supports a four-year research initiative investigating the effect of caloric restriction on aging biomarkers, frailty, and multimorbidity in older adults with obesity. The primary research objective is to determine whether short-term caloric...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $599,623 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with a completion date of January 31, 2031. This five-year research initiative investigates the synergistic effects of unacylated ghrelin (UnAG) and endurance exercise (EE) as an intervention strategy to combat sarcopenia and mobility loss in aging populations. The research builds on preliminary...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $6.42 million Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded September 15, 2025, with completion scheduled for September 14, 2029. This award supports a longitudinal research initiative examining how Mediterranean versus Western diet composition moderates cognitive aging trajectories and neuropathology in middle-aged male and female cynomolgus monkeys. The...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $1.54 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded July 1, 2025, with completion scheduled for March 31, 2030. The award supports research on neuroimaging-genomic fingerprints for subtyping and prediction of Alzheimer's disease and related dementia. The project develops data-driven computational models integrating multi-modal imaging and...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $668,290 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 15, 2026, with a completion date of January 31, 2031. The grant funds a five-year research initiative to investigate the metabolism and protective role of docosahexaenoic acid (DHA), an omega-3 essential nutrient implicated in disease prevention but deficient in approximately 80% of the U.S. population....
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts a $1.35 million Project Grant effective August 15, 2025, through July 31, 2030, under the Aging Research program (CFDA 93.866). This research initiative investigates the neuromechanical bases for increased energy cost of walking in older adults, a significant contributor to age-related mobility loss and a major public health concern. The project will deliver comprehensive...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a $518,372 Project Grant effective May 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This research project will investigate the mechanisms by which bone marrow adipocytes (BMADs) regulate bone health and protect against age- and disease-associated bone loss. The research will produce scientific knowledge regarding neuro-adipose-bone crosstalk within the...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Wisconsin-Madison a $1,198,259 Project Grant effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports biomedical research investigating the physiological and molecular mechanisms underlying calorie restriction (CR), prolonged fasting, and mTORC1 protein kinase function in aging and age-related diseases. The research employs multiple...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $426,250 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026 through January 31, 2028 to conduct a randomized, double-blind, placebo-controlled clinical trial investigating vibegron as a therapeutic intervention for multisystem functional decline in aging and obesity. Vibegron, an FDA-approved beta-3 adrenergic receptor (β3AR) agonist, will be...
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a Project Grant totaling $427,625.00 under the Aging Research program (CFDA 93.866) for the period of February 15, 2026, through January 31, 2028. The award funds research investigating intramuscular adipose tissue (IMAT) quality in aging and its relationship to muscle weakness and physical dysfunction in older adults. The research will deliver scientific findings through two parallel research aims: (1)...
Wake Forest University Health Sciences received a $417,545 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for a two-year project period (June 1, 2026 – May 31, 2028). The award funds a pooled analysis examining the long-term legacy effects of caloric restriction (CR) and exercise (EX) interventions on bone strength in older adults with obesity. The research leverages existing data from five National Institutes of Health-supported clinical trials conducted between 2005 and 2014, plus follow-up assessments from the Health Outcomes After Participating in Exercise (HOPE) study conducted approximately 10 years post-intervention. The project will analyze quantitative computed tomography (QCT) scans and apply finite element modeling to assess 272 participants' bone strength, including three-dimensional bone morphology, volumetric bone mineral density, and cortical thickness measurements. The primary deliverable is a comprehensive analysis determining whether prior randomization to combined CR+EX versus EX alone produces differential long-term effects on biomechanical bone strength in older adults. This research addresses a significant clinical gap regarding the sustainability and safety of weight-loss interventions in aging populations, where concerns exist that interventions may exacerbate musculoskeletal losses and increase osteoporotic fracture risk. By employing more robust bone assessment methodologies than standard dual-energy x-ray absorptiometry, this investigation will inform evidence-based clinical recommendations for obesity treatment in older age.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $417.5k | 5/25/26 |