The University of Wisconsin-Madison was awarded a $1,271,506 Project Grant by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The goal of this 5-year award, effective July 1, 2025, is to catalyze research at the interface of aging, metabolism, and translation. The project aims to create an environment and infrastructure that will have a significant impact on aging biology research both locally and nationally. Key focus areas include advancing...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $425,958 to the University of Arizona to study the role of the hormone glucagon in mediating the health and longevity benefits of calorie restriction in humans. The key objectives are to: 1) Measure serum levels of glucagon, glucagon-like peptide-1 (GLP-1), and fibroblast growth factor 21 (FGF21) in participants of the CALERIE calorie restriction trial at baseline, 12 months, and 24 months...
This $659,916 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to test the ability of diets with reduced levels of specific amino acids (isoleucine, valine, or histidine) to reverse diet-induced obesity and insulin resistance. The primary objectives are to determine the optimal degree of amino acid restriction to promote metabolic health in animal models, and to evaluate the efficacy of an optimized amino acid-restricted diet in...
The U.S. National Institute on Aging awarded a $467,416 Project Grant (R21AG085086) to Tufts University School of Medicine to investigate the effects of calorie restriction on mitochondrial DNA integrity and its relationship to biological aging and cardiometabolic health. The study will analyze mitochondrial DNA heteroplasmy changes over two years in participants from the CALERIE clinical trial, which examined the long-term effects of calorie restriction. The project aims to determine if calorie...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $2,496,057.49 to the University of Arizona to investigate the role of hepatic glucagon receptor signaling in healthspan and aging. The research aims to study the impact of genetic and pharmacological manipulation of glucagon receptor signaling on normal aging, obesity-accelerated aging, and the effects of calorie restriction. This work seeks to identify glucagon receptor...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,512.00 to the Regents of the University of Minnesota to conduct research on the relationship between lipid metabolism, mitochondrial stress, and cellular senescence. The key objectives are to: 1) use proteomics to characterize mitochondrial protein targets of carbonylation during obesity and aging, and 2) investigate the role of mitochondrial stress and signaling on adipose tissue...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $385,612 aims to integrate experimental and computational models to study prefrontal microcircuit changes during healthy aging and Alzheimer's disease progression. The research team at the University of Wyoming will use in vivo calcium imaging, computational simulation modeling, and neural decoding to directly visualize and predict microcircuit changes in the prefrontal cortex. A sub-award of an...