Project Grant R01AG092766
- Federal Project Grant Award Summary The National Institute on Aging awarded a $673,012 Project Grant to the University of Massachusetts, beginning August 15, 2025, and extending through July 31, 2030, under the Aging Research program (CFDA 93.866). This research project will investigate the neuromechanical bases for increased energy cost of walking in older adults, a significant contributor to age-related mobility loss and a major public health concern. The research will examine how...
- Federal Project Grant Award Summary The National Institute on Aging awarded $698,690 to the University of Wisconsin-Madison under its Aging Research program (CFDA 93.866) effective February 1, 2026, through January 31, 2031. This Project Grant supports basic research investigating the molecular mechanisms underlying fiber type-specific skeletal muscle dysfunction in aging populations. The research project will deliver scientific findings and data products examining how aging affects slow...
- Federal Grant Award Summary Panorama Research Incorporated received a $354,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of September 20, 2025, and completion date of September 19, 2026. The company will develop novel therapeutic formulations of Isthmin 1 (ISM1), an adipokine designed to address sarcopenia—age-related loss of skeletal muscle mass, strength, and quality. The research will generate...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
- Federal Grant Award Summary The National Institute on Aging awarded a $116,710 Project Grant to the University of Connecticut, Office Sponsored Programs, effective August 1, 2025 through April 30, 2030, under the Aging Research program (CFDA 93.866). This career development award supports research to establish sex-specific determinants of muscle quality in older adults, with particular focus on understanding how males and females experience different mechanisms of sarcopenia—the age-related loss...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- Federal Grant Award Summary The National Institute on Aging awarded Rutgers, The State University $909,876 under the Aging Research program (CFDA 93.866) through a Project Grant mechanism to conduct fundamental research on the molecular and cellular mechanisms underlying exercise-induced protection of the aging nervous system. The award, obligated on August 15, 2025, with a completion date of July 31, 2027, supports a collaborative research initiative using Caenorhabditis elegans (C. elegans) as...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Pennington Biomedical Research Center $749,481 under the Aging Research program (CFDA 93.866) effective January 1, 2026, through December 31, 2030. This project grant funds a 12-week randomized controlled feeding trial investigating the effects of low energy density dietary intervention combined with exercise on metabolic and musculoskeletal outcomes in older adults with obesity and insulin resistance. The study...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
This Project Grant award of $599,623 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2031, funds biomedical research conducted by Wake Forest University Health Sciences to investigate the synergistic effects of unacylated ghrelin (UNAG) and endurance exercise (EE) on sarcopenia and mobility loss in aging populations. The research addresses a critical gap in gerontological science by examining how the combination of UNAG supplementation with exercise training can enhance mitochondrial bioenergetics, preserve neuromuscular junction integrity, and improve muscle mass and contractile function in older adults—outcomes that previous intervention approaches using metformin and antioxidants failed to achieve when combined with exercise. The deliverables under this award include scientific research findings, experimental data, and mechanistic insights regarding the complementary and synergistic pathways activated by UNAG+EE treatment, with particular focus on mitochondrial respiration, motor coordination, and functional mobility preservation. As a component of the NIA's broader mission to support biomedical and behavioral research advancing understanding of aging processes and age-related conditions, this project is expected to generate peer-reviewed publications, establish foundational evidence for potential therapeutic interventions against sarcopenia, and contribute to the evidence base for preventing mobility loss and promoting independence in older adults.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $599.6k | 1/29/26 |