Project Grant R01AG095946
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $650,872 Project Grant to The Johns Hopkins University to investigate the bioenergetic, physiological, and gait mechanics mechanisms that contribute to the high energetic cost of walking in older adults. The 5-year project, which began on August 15, 2025, will use clinical, laboratory, and sensor-based assessments to detect changes in health and mobility consistent with the onset and...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to identify multi-scale mechanisms contributing to age-related increases in the metabolic cost of walking and decreases in walking speed. The $3,224,215 award to Georgia Tech Research Corp, to be completed by July 31, 2029, will leverage a multi-scale, computational-experimental approach to probe the cellular-to-behavioral mechanisms linking the...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $245,434 to Wake Forest University Health Sciences to conduct research on preserving muscle and bone health in older adults undergoing weight loss interventions. The 2.5-year project aims to develop automated analysis techniques to measure changes in muscle quantity and quality, as well as bone strength, using computed tomography (CT) scans collected as part of an ongoing clinical trial....
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
- This $423,147 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University will fund research to understand the effects of mild cognitive impairment (MCI) and Alzheimer's disease (AD) on gait function and locomotor flexibility. The project will compare split-belt treadmill adaptation, gait performance, and cognitive function between healthy older adults, those with MCI, and those with AD. Longitudinal assessments will track disease...
- This $454,938 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to define the impact of exercise on the aging nervous system. The project, led by Rutgers, The State University, will leverage the C. elegans worm model to characterize how regular exercise protects the nervous system against age-related dysfunction, including neuronal hyperactivity similar to brain aging in mammals. The research aims to elucidate the molecular...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $405,045.00 to the University of Florida to study the neural mechanisms underlying locomotor adaptation deficits and freezing of gait in Parkinson's disease (PD) patients. The project aims to understand how abnormal neural oscillations in the globus pallidus internus (GPI) disrupt the regulation of human walking in PD. The research will utilize a split-belt treadmill paradigm and record local...
- This $665,970 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate how mechanical loading protocols, such as exercise and nutrition, can regulate knee joint health and potentially ameliorate age-related knee osteoarthritis. The award will fund a 5-year research project conducted by an interdisciplinary team at The Spaulding Rehabilitation Hospital Corporation in Massachusetts. The project aims to use innovative approaches,...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
This Project Grant award of $673,012 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to understand the neuromechanical bases for the increased energy cost of walking in aging. The University of Massachusetts is the primary awardee, with the goal of determining how age-related changes in gait strategy combine with muscle weaknesses to increase the energy cost of walking in older adults. The research will address key knowledge gaps regarding relative changes in muscle strength and size, the impact of joint work distribution on neuromechanical demands, and potential muscle bioenergetic deficits contributing to greater walking energy costs. Findings from this 5-year project are expected to provide critical insights into the underlying mechanisms driving age-related mobility loss, a major public health concern.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $673.0k | 8/11/25 |