Project Grant R01AG101404
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant of $427,625 under the Aging Research program (CFDA 93.866) on February 15, 2026, with completion targeted for January 31, 2028. This award supports biomedical research investigating intramuscular adipose tissue (IMAT) quality in aging populations and its relationship to muscle weakness and physical dysfunction. The research will deliver scientific knowledge through two...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant of $150,114 under the Aging Research program (CFDA 93.866) with an award date of March 18, 2026, and completion date of November 30, 2027. This grant supports biomedical research investigating the role of brain-engrafted monocyte-derived macrophages (MDMs) in Alzheimer's disease (AD) pathogenesis. The research aims to elucidate how MDMs contribute to AD pathology through dual-phase...
- Summary of Federal Project Grant Award The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $593,146 under the Aging Research program (CFDA 93.866) for the period of January 1, 2026 through November 30, 2030. The research project, titled "Mechanisms of Activity-Dependent Transcription and DNA Repair in Neuronal Longevity," will generate scientific knowledge regarding the cellular and molecular basis of brain aging and cognitive decline. The...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a $1,746,856 Project Grant effective August 5, 2025, through April 30, 2030, under the Aging Research program (CFDA 93.866). This award supports research investigating the role of senescent cancer-associated fibroblasts (SenCAFs) in breast cancer progression, with particular focus on age-related changes in the tumor microenvironment. The research utilizes advanced immunological and biophysical...
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a Project Grant in the amount of $556,121 under the Aging Research program (CFDA 93.866) on January 15, 2026. The award supports research through December 31, 2030, conducted at the university's St. Louis, Missouri facility. The project investigates transgenerational epigenetic adaptation and longevity changes in response to repeated environmental stresses, utilizing Caenorhabditis elegans (C....
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Indiana University Indianapolis $3,126,515 on August 15, 2025, under the Aging Research program (CFDA 93.866) to support research investigating a novel inter-tissue L-BAIBA/FGF23 (L-beta-aminoisobutyric acid/fibroblast growth factor 23) signaling axis as a therapeutic target for enhancing musculoskeletal remodeling in aging populations. The research project, with a completion date of May 31, 2029, will generate...
- Federal Grant Award Summary The National Institute on Aging (part of the National Institutes of Health) awarded a Project Grant of $627,212 to the University of California, Davis under the Aging Research program (CFDA 93.866) on May 15, 2026, with a completion date of January 31, 2031. This award supports biomedical research directed toward understanding and treating age-related diseases, specifically osteoarthritis (OA). The research focuses on developing and validating stem cell-based...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University $3,188,901 under the Aging Research program (CFDA 93.866) for a four-year project beginning September 1, 2025, and concluding August 31, 2029. This project grant supports research to map amyloid, tau, and neurodegeneration (ATN) biomarkers in relation to neuropsychiatric phenotypes and genotypes across the Alzheimer's disease continuum using machine learning methodologies. The research...
- Federal Project Grant Award Summary New York University School of Medicine received a $466,125 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective January 15, 2026 through December 31, 2027. The project develops innovative analytical tools and frameworks for non-invasive biomarker identification in skeletal muscle health assessment. Specifically, the research produces magnetic resonance imaging (MRI) analysis methodologies designed...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $146,070 Project Grant to the University of Texas at Austin, effective September 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). This award supports research investigating how the accumulation of senescent cells and their secretory phenotypes impact osteocyte mechanobiology—the ability of bone cells to sense and respond to mechanical stimuli. The project will develop novel...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded The Washington University a project grant of $518,372 effective May 1, 2026, through January 31, 2031. This research project investigates the regulatory mechanisms and functional roles of bone marrow adipose tissue (BMAT) and bone marrow adipocytes (BMADs) in skeletal health and neural regulation of bone. The primary deliverables include scientific research characterizing neuro-adipose-bone crosstalk within the bone marrow niche, development of bioinformatic-based digital twin models to computationally predict personalized strategies for preserving skeletal integrity, and identification of mechanisms underlying bone marrow adipocyte-mediated protection against age- and disease-associated bone loss. The research comprises two specific aims: Aim 1 defines the mechanisms of bone marrow adipocyte-mediated bone anabolism and protection while creating computational models informed by findings in aged and post-menopausal states, and Aim 2 isolates the fate of catabolized bone marrow adipocytes and quantifies changes in bone and muscle following complete bone marrow adipocyte loss. Findings will support the development of novel therapeutic strategies to mitigate bone loss in states of high sympathetic tone, neurosystemic stress, and various wasting and cachexia conditions, with direct applications to healthy skeletal aging and fracture prevention across diverse patient populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $518.4k | 5/4/26 |