Project Grant R21AG091159
- Summary of Federal Project Grant Award The National Institute on Aging (NIA) awarded The Washington University a $128,373 Project Grant effective August 15, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). This research initiative will develop and compare state-of-the-art biological aging "clock" models across three complementary physiological measurement modalities: epigenetic (DNA methylation), proteomic (protein concentration), and neuroimaging (brain...
- Federal Grant Award Summary Panorama Research Incorporated received a $354,000 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 20, 2025, with a completion date of September 19, 2026. The award supports the development of novel therapeutic candidates based on Isthmin 1 (ISM1), an adipokine designed to address sarcopenia—the age-related loss of skeletal muscle mass, strength, and quality—while preserving muscle function in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $698,690 Project Grant to the University of Wisconsin–Madison, effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This award supports research investigating the molecular mechanisms underlying fiber type-specific skeletal muscle dysfunction with aging. The research will deliver three primary products: (1) quantified proteome changes associated with fiber...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Pennington Biomedical Research Center a Project Grant of $749,481 under the Aging Research program (CFDA 93.866) beginning January 1, 2026, and concluding December 31, 2030. This grant funds a 12-week randomized controlled trial investigating the effects of a low energy density diet combined with exercise on body composition and metabolic outcomes in 80 older adults (age 50+) with obesity and insulin resistance. The...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $599,623 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with a project completion date of January 31, 2031. This five-year research initiative investigates the synergistic effects of unacylated ghrelin (UNAG) combined with endurance exercise (EE) as an intervention to combat sarcopenia—the progressive loss of muscle mass and...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a $1.85M project grant effective June 1, 2025, through March 31, 2030, under the Aging Research program (CFDA 93.866). The research initiative, titled "First In Last Out: How Development Informs Neurodegeneration," investigates the biological mechanisms linking early brain development to Alzheimer's disease (AD) pathology in later life. The project will deliver empirical research...
- Federal Grant Award Summary The National Institute on Aging awarded a $2,631,670 Project Grant to Washington University (Award Date: September 1, 2025; Completion Date: August 31, 2029) under the Aging Research program (CFDA 93.866) to investigate age-related deficits in episodic memory for both content and structure of naturalistic events. The research will deliver scientific findings examining how aging distinctly affects memory representations and their relationship to dysfunction in...
- Federal Project Grant Award Summary New York University School of Medicine received a $466,125 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective January 15, 2026, through December 31, 2027. The award funds the development of innovative magnetic resonance imaging (MRI) analysis tools and frameworks designed to identify microstructural and structural biomarkers of skeletal muscle health across the lifespan. The research specifically...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- Federal Grant Award Summary The National Institute on Aging awarded a Project Grant of $556,121 to The Washington University (award date: January 15, 2026; completion date: December 31, 2030) under the Aging Research program (CFDA 93.866) to conduct scientific research on transgenerational epigenetic adaptation in response to repeated environmental stresses. The research will investigate how successive generational exposures to environmental stressors influence complex organismal traits,...
The National Institute on Aging awarded The Washington University a Project Grant totaling $427,625 under the Aging Research program (CFDA 93.866) for research investigating intramuscular adipose tissue (IMAT) quality in aging populations. The award, effective February 15, 2026 through January 31, 2028, supports a two-pronged research initiative examining how senescent changes in IMAT contribute to age-related muscle weakness and physical dysfunction. The research combines human clinical studies and mouse model investigations to evaluate the effects of a 12-week progressive resistance exercise program on IMAT senescence across different age groups (~30% and ~80% of lifespan). Primary objectives include assessing IMAT senescent and signaling changes with age and exercise through direct cellular analysis in human subjects, and determining whether age- and exercise-responsive IMAT features identified in humans are replicable in a toxin-induced mouse IMAT model. The deliverables from this project are expected to advance understanding of the mechanisms linking intramuscular adipose accumulation to age-related muscle dysfunction and identify whether exercise-based or combined pharmacologic interventions can modify senescent IMAT characteristics to improve muscle signaling. This research directly supports the National Institute on Aging's mission to identify prevention and treatment strategies for age-related health conditions affecting millions of Americans, with potential long-term applications in developing therapeutic targets to address progressive muscle weakness in aging populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 2/4/26 |