Project Grant RF1AG092490
- This $2,366,213 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund the INLIFE (Individualized Lifestyle Change for Every Aging Brain) study. The study aims to harmonize and analyze participant-level data from 12 U.S. randomized controlled trials to examine how changes in lifestyle behaviors such as physical activity, cognitive activity, diet, and social engagement impact cognitive outcomes across diverse older adult populations....
- The National Institute on Aging (NIA) awarded a $2,168,393 Project Grant (CFDA 93.866) to Yale University to examine the role of kynurenic acid in age-related cognitive deficits. The 3-year grant, starting September 1, 2023, will study how increased kynurenine inflammatory signaling with aging impairs higher cortical function in the dorsolateral prefrontal cortex (DLPFC) through blockade of NMDAR and α7-nAChR receptors, leading to working memory deficits. The research will test strategies to...
- This Project Grant award from the National Institute on Aging's (NIA) Aging Research Federal Grant Program (CFDA 93.866) is funding a $109,595 project at the University of California, Davis to characterize a novel non-human primate model of Alzheimer's disease. The project aims to perform comprehensive microscopic analyses to determine the patterns of tau-based neuropathology, neuronal loss, synaptic health, and neural circuit functionality in the brains of rhesus macaques with progressive tau...
- This Project Grant award of $1,602,696 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the relationship between obesity, cognitive impairment, and neurological disorders such as Alzheimer's disease. The research aims to use magnetic resonance imaging (MRI) techniques to assess neurovascular and lymphatic changes, neuroinflammation, and blood-brain barrier dysfunction in mouse models of obesity-linked cognitive decline. The goal is to identify...
- This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, provides $2,330,859.00 in funding to study age-related changes in brain network connectivity and their relationship to cognitive decline. The 3-year project aims to use multimodal neuroimaging, single-cell transcriptomics, electrophysiology, and neural tract-tracing in a rhesus monkey model to delineate how...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $770,558 project grant to Wake Forest University Health Sciences (WFUHS) to establish connections between Alzheimer's disease (AD)-related genomic markers and neuroimaging phenotypes. The objective is to determine the heterogeneity of AD subtypes and their association with the clinical onset of dementia. The project aims to develop data-driven computational models using multi-modal...
- This $4,444,978 federal Project Grant award, issued by the National Institute on Aging (CFDA 93.866 Aging Research program), supports research to characterize cognitive reserve and identify modifiable factors that promote cognitive reserve and resilience to Alzheimer's disease and related dementias (ADRD) among older adults in India, with a focus on those who lack formal education. The project aims to: 1) compare brain pathology measures and their contributions to cognition between older...
- The National Institute on Aging (NIA) awarded a $405,849 Project Grant (CFDA 93.866 - Aging Research) to the Keck Graduate Institute of Applied Life Sciences to investigate the impact of obesity-induced hepatic amyloid beta dysregulation on Alzheimer's disease pathology. The key objectives are to: Examine the relationship between changes in peripheral and hepatic amyloid beta with brain amyloid beta load and Alzheimer's disease pathology in Alzheimer's disease mice fed a high-fat/high-sugar...
- This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
This $6,424,607 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the impact of Mediterranean vs. Western diet on cognitive function, and neurological biomarkers associated with Alzheimer's disease risk, in middle-aged male and female cynomolgus monkeys. The 4-year longitudinal study, awarded to Wake Forest University Health Sciences, aims to provide critical insight into the mechanisms by which diet composition can modulate brain aging trajectories using a nonhuman primate model. The research will assess the effects of these dietary interventions on cognitive performance, neuroimaging biomarkers, and transcriptional profiles related to inflammation and neurodegeneration, with the goal of advancing scientific understanding of the relationship between nutrition and brain health as individuals age.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $6.4m | 9/10/25 |