Project Grant R01EY037802
- The National Eye Institute awarded the University of Pittsburgh $433,324 under the Vision Research program (CFDA 93.867) on September 1, 2026, to develop next-generation microfluidic platforms for high-throughput screening of axon growth-promoting compounds as potential regeneration therapies for glaucoma and optic neuropathies. The project focuses on addressing limitations in conventional axon growth assays by engineering microfluidic devices that enable defined chemoattractant gradients,...
- The National Eye Institute awarded The University of Texas Southwestern Medical Center $456,500 on July 1, 2026, under the Vision Research program (CFDA 93.867, Assistance Listing) for spatial molecular profiling of optic nerve injury and assessment of extracellular matrix (ECM) proteins. The research examines why regenerated retinal ganglion cell (RGC) axons fail to reach the brain after optic nerve injury, instead following circuitous pathways within fibrotic scars—a phenomenon the...
- The National Eye Institute awarded The Johns Hopkins University $698,999 on July 1, 2026, under the Vision Research program (CFDA 93.867) to conduct research on mechanisms of functional retinal engraftment by transplanted retinal ganglion cells for optic neuropathies including glaucoma. The project addresses the death of retinal ganglion cells (RGCs), which transmit visual information from the eye to the brain. While existing treatments slow vision loss in some progressive optic neuropathies, no...
- The National Eye Institute awarded the University of California, San Diego $701,576 on July 1, 2026, under the Vision Research program (CFDA 93.867) to explore retinal ganglion cell endogenous repair after injury using engineered human pluripotent stem cells. The research uses human pluripotent stem cell-derived 3D retinal organoids as a model to investigate glia-to-neuron repair mechanisms in the retina. Work focuses on how transcription factors enable Müller glia to respond to injury and...
- The National Institutes of Health National Eye Institute awarded the University of Connecticut Health Center $416,250 on April 15, 2026, under the Vision Research program (CFDA 93.867) to investigate NFE2L3-regulated mechanisms of retinal ganglion cell neuroprotection and optic nerve axon regeneration. The research examines molecular mechanisms through which the NFE2L3 protein regulates regeneration of damaged optic nerve axons in retinal ganglion cells. The project uses established animal...
- The National Eye Institute awarded The Johns Hopkins University $682,679 under the Vision Research program (CFDA 93.867) on July 1, 2026, to identify drivers of retinal ganglion cell differentiation from endogenous stem cells. The research aims to characterize how retinal ganglion cells regenerate in zebrafish, identify the signals that regulate this regeneration, and discover factors that drive regeneration independently of cell loss. Retinal ganglion cells are the sole neurons capable of...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $2,271,828 to The University of Texas Southwestern Medical Center on September 1, 2026, under the Vision Research program (CFDA 93.867). The recipient will conduct research into the cellular and molecular mechanisms governing optic nerve myelin integrity, with emphasis on understanding how myelin whorls—multilayered degenerative myelin structures that appear in demyelinating...
- The National Eye Institute, part of the Department of Health and Human Services, awarded $458,288 to the University of Washington on May 1, 2026, under the Vision Research program (CFDA 93.867, Assistance Listing designation Project Grant). The award funds research into stimulation of regeneration in the human retina. The investigator team will test whether expressing the proneural regulatory gene ASCL1 in Müller glia can induce regeneration of retinal neurons in human tissue and adult non-human...
- The National Eye Institute awarded The Regents of the University of California, San Francisco $255,340 on May 1, 2026, under the Vision Research program (CFDA 93.867) to support development and regeneration of retinal ganglion cells in the vertebrate retina. The award funds a career development project investigating gene regulatory networks that direct retinal ganglion cell differentiation during development and applying those insights to regenerate retinal ganglion cells from dormant progenitor...
- The National Eye Institute awarded the University of Pennsylvania $674,423 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of retinal microsomal triglyceride transfer protein (MTP) in vision and lipid homeostasis. The research examines how MTP regulates the assembly and secretion of apoprotein B-containing lipoproteins in the retinal pigment epithelium (RPE), which transport lipids and prevent pathologic lipid accumulation linked to retinal...
The National Eye Institute awarded The Trustees of The University of Pennsylvania $719,199 on August 5, 2026, under the Vision Research program (CFDA 93.867) to advance understanding of retinal ganglion cell and optic nerve regeneration following injury and optic neuropathies. The research will employ single-cell CRISPR screening (perturb-seq) to systematically identify genes and gene combinations whose suppression most effectively promotes retinal ganglion cell and optic nerve regeneration following injury. The project will also use spatial transcriptomics to map cellular interactions and molecular signaling networks in the injured retina and optic nerve, pinpointing spatially and temporally resolved targets that may influence the regenerative process. By integrating findings from both approaches, the research will establish a comprehensive framework for understanding the molecular and cellular mechanisms underlying regenerative failure in optic neuropathies and will guide development of new therapeutic strategies for enhancing neural repair and restoring vision following acute optic nerve injury. The award funds work at the University of Pennsylvania in Philadelphia, Pennsylvania, with a period of performance extending through April 30, 2031. This is a project grant, the standard NIH investigator-initiated research assistance type under the Vision Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $719.2k | 8/7/26 |