Project Grant R01EY037243
- Federal Grant Award Summary The University of Washington received a $345,086 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective June 1, 2025 through March 15, 2028. The research investigates the roles of parvalbumin-expressing (PV+) neurons in primate cortical visual processing, with a focus on determining whether these inhibitory neurons mediate gain control—the neural mechanism that adjusts sensory sensitivity to maintain firing rates...
- Federal Grant Award Summary The University of Washington received a $503,525 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) for the period May 1, 2026 through April 30, 2028. The research project, titled "Direction-Specific Processing in the Cerebellar Oculomotor Vermis During Saccades," will deliver fundamental neuroscience research aimed at understanding how the cerebellum processes motor signals to regulate precise eye...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Johns Hopkins University a $695,018 Project Grant effective August 1, 2025, through July 31, 2030, to conduct research on the regulation of retinal ganglion cell regeneration through Müller glia (MG) cell function. The award supports a five-year investigation into how MG cells function as injury-responsive stem cells to enable retinal regeneration, with the ultimate goal...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded the University of Washington a $699,739 Project Grant effective August 1, 2025, through July 31, 2030, under the Vision Research program (CFDA 93.867). This award funds the development and application of novel chemical biology tools to investigate the molecular and cellular mechanisms underlying Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel regulation by nerve growth factor (NGF). The research deliverables...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Johns Hopkins University a Vision Research grant (CFDA 93.867) totaling $173,286.17 to evaluate the regenerative potential of human retinal ganglion cells (RGCs). This project, which commenced June 1, 2025, addresses a critical barrier to vision restoration by investigating whether intrinsic factors regulating RGC survival and neurite outgrowth can be modulated to promote axonal regeneration and optic nerve...
- Federal Grant Award Summary Baylor College of Medicine received a $1.6 million project grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 30, 2025, with completion scheduled for September 29, 2028. The research investigates the molecular mechanisms governing Muller glial cell (MGC) reprogramming and proliferation through modulation of the Hippo and Wnt signaling pathways. The project aims to identify cellular and molecular strategies to...
- Federal Project Grant Award Summary Wayne State University received a $385,000 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective August 1, 2025 through July 31, 2029. The grant supports research investigating genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research utilizes zebrafish models to compare transcriptional, cellular, and functional changes occurring during chronic and...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $427,625 under the Vision Research program (CFDA 93.867) to The Washington University for a two-year project (April 1, 2026 – March 31, 2028) to develop novel statistical methodologies for detecting and characterizing visual field progression in primary open-angle glaucoma (POAG). The primary deliverables include: (1) a change-point statistical model integrating longitudinal mean deviation measures to identify early disease...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Washington University a $1,001,009 Vision Research (CFDA 93.867) Project Grant effective July 1, 2025, with a completion date of March 31, 2030. This award funds fundamental research investigating how visual signals for eye fixation and optokinetic reflex (OKR)—a reflexive eye movement triggered by peripheral visual motion—interact within the retina. The research directly addresses a significant gap in understanding...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $255,340 through the Vision Research program (CFDA 93.867) to The Regents of the University of California, San Francisco for a five-year project (May 1, 2026 – April 30, 2031) focused on understanding and regenerating retinal ganglion cells in the vertebrate retina. This research addresses glaucoma, which affects over four million Americans and represents the second leading cause of irreversible blindness globally. The...
The University of Washington received a $458,288 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2026 through February 28, 2030. This five-year research initiative will advance regenerative therapies for retinal neuron loss by investigating methods to stimulate Müller glia cells to regenerate damaged retinal neurons in humans and non-human primates. The project will deliver research products including validation of ASCL1 (Achaete-scute homolog 1) gene expression techniques in human Müller glia, identification of specific transcription factor combinations that effectively regenerate cone photoreceptors, and investigation of epigenetic factors that may enhance regeneration efficiency across all retinal neuron types. This research addresses a critical gap in vision care by translating regenerative mechanisms observed in non-mammalian vertebrates to mammalian systems, with potential applications for patients with glaucoma, macular degeneration, and retinal trauma. The anticipated outcomes include refined protocols for inducing functional neuron regeneration in humans and a comprehensive strategy document for treating retinal disease, which will establish the scientific foundation for future regenerative therapeutic development for vision loss conditions currently lacking effective treatment options.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $458.3k | 4/16/26 |