Project Grant R01EY037472
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $255,340 Project Grant to The Regents of the University of California, San Francisco, effective May 1, 2026, through April 30, 2031, under the Vision Research program (CFDA 93.867). This award supports fundamental research into the development and regeneration of retinal ganglion cells in the vertebrate retina, with the goal of developing therapeutic strategies to restore vision in patients with glaucoma and other retinal...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded a $902,000 Project Grant to The Regents of the University of California, San Francisco under the Vision Research program (CFDA 93.867) effective September 1, 2025, through August 31, 2027. This award funds research to characterize a novel GLIS1 knockout (KO) mouse model of glaucoma, addressing the critical need for therapeutic strategies targeting neuroprotection in primary open-angle glaucoma (POAG), a leading cause of...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $682,679 Project Grant to The Johns Hopkins University effective July 1, 2026, through January 31, 2030. This research initiative focuses on identifying drivers of retinal ganglion cell (RGC) differentiation from endogenous stem cells—a critical area given that RGCs are the sole neurons capable of relaying visual information from the retina to the brain, and their loss can...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $127,180 under the Vision Research program (CFDA 93.867) to The Regents of the University of California, San Francisco, effective July 1, 2026, through June 30, 2028. This two-year project grant funds basic science research investigating the role of perivascular retinal ganglion cells (RGCs) in regulating retinal vascular architecture and neurovascular resilience. The research focuses on a specialized subset of RGCs...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $437,262 to the University of California, Davis for a project investigating the functions of PAX2-expressing astrocytes in postnatal retinal and optic nerve development. The award, effective July 1, 2026, through March 31, 2030, will deliver research findings addressing the underlying causes of human ocular disorders, particularly congenital cavitary optic disc anomalies...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded the University of California, Davis $423,767 under the Vision Research program (CFDA 93.867) for a two-year project period beginning June 1, 2025 and concluding May 31, 2027. The research project investigates the role of myeloid cells as mediators of glaucomatous axon degeneration and evaluates whether nicotinamide adenine dinucleotide (NAD+)-boosting interventions provide neuroprotection through anti-inflammatory...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded the University of California, San Francisco a Project Grant of $737,998 effective July 1, 2026, through March 31, 2031, under the Vision Research program (CFDA 93.867). This award funds research to define area-specific cellular and circuit-level specialization in the human temporal cortex, with particular focus on identifying electrophysiological and synaptic features unique to excitatory neurons in the inferior...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $128,610 to the University of California, San Diego effective December 1, 2025, with a completion date of May 18, 2029. This Project Grant supports research to elucidate the role of Thousand and One (TAO) kinases in retinal ganglion cell (RGC) death and axon injury signaling pathways relevant to glaucoma. The research investigates how TAO kinase 1 and 2 (TAOK1/2) regulate the...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $900,600 Project Grant to The Regents of the University of California, San Francisco effective September 1, 2025, with completion targeted for August 31, 2027. This award funds research to advance understanding of corneal limbal stem cells (LSCs) during wound healing, with the objective of developing restorative treatments for corneal damage—a leading cause of...
- Federal Project Grant Award Summary The University of Washington, through its Office of Sponsored Programs, received a $458,288 Project Grant award dated May 1, 2026, from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867). The award funds a five-year research initiative—extending through February 28, 2030—focused on stimulating regeneration in the human retina to develop therapeutic interventions for retinal neuron loss associated with degenerative diseases such as...
The National Eye Institute (NEI) awarded a $701,576 Project Grant to the University of California, San Diego, effective July 1, 2026, through April 30, 2030, under the Vision Research program (CFDA 93.867). The award funds research to explore endogenous retinal ganglion cell (RGC) repair mechanisms following injury using engineered human pluripotent stem cell (PSC)-derived three-dimensional retinal organoids as a model system. The research addresses the critical gap in understanding how transcription factors enable Müller glial cells to respond to retinal injury and differentiate into RGCs, processes that occur naturally in regenerative species but have been lost in mammals, contributing to permanent vision loss in glaucoma and other optic neuropathies. Under the award, researchers will conduct a multi-aim investigation utilizing advanced molecular techniques including AAV-delivered transcription factor overexpression, CRISPR interference gene suppression, and drug-inducible caspase-mediated cell ablation models to systematically study glia-to-neuron conversion pathways. The work aims to identify and characterize the sequential waves of transcription factor signaling that promote Müller glial cell proliferation and neurogenesis, while simultaneously investigating regeneration roadblocks and the role of injury signals in activating endogenous repair mechanisms. These research outputs will generate foundational knowledge applicable to developing therapeutic interventions for sight-threatening retinal diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $701.6k | 6/30/26 |