Project Grant K08EY038342
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $902,000 to the University of California, San Francisco for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The primary deliverables include comprehensive phenotypic characterization of GLIS1 knockout mice across two genetic backgrounds, evaluating structural and functional...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Regents of the University of California, San Francisco (UCSF) a Project Grant of $321,364 under the Vision Research program (CFDA 93.867) for the project "Neural Mechanisms of Sensory Encoding After Photoreceptor Degeneration." The award, effective June 1, 2025, through December 31, 2027, will fund fundamental research investigating how neural circuits in the retina adapt and compensate when cone photoreceptors...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $255,722 under the Vision Research program (CFDA 93.867) to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027. This Project Grant supports fundamental research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The research deliverables include scientific findings on how lipoxin B4 (LXB4), an endogenous lipoxin produced by retinal...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded the University of California, Davis $423,767 under the Vision Research program (CFDA 93.867) for a two-year project period beginning June 1, 2025 and concluding May 31, 2027. The research project investigates the role of myeloid cells as mediators of glaucomatous axon degeneration and evaluates whether nicotinamide adenine dinucleotide (NAD+)-boosting interventions provide neuroprotection through anti-inflammatory...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant totaling $900,600 to The Regents of the University of California, San Francisco, with an award date of September 1, 2025, and completion date of August 31, 2027, under the Vision Research program (CFDA 93.867). This award funds research directed at understanding corneal limbal stem cells (LSCs) during wound healing processes. The project addresses the significant clinical need for restorative treatments for...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded UC Berkeley a $481,500 Project Grant under the Vision Research program (CFDA 93.867) effective September 1, 2025 through August 31, 2026. The grant funds fundamental research investigating the role of retinal waves in vascular development, specifically examining neural-glial-vascular signaling mechanisms that regulate blood vessel formation in the developing retina. This research directly addresses clinical applications for...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Johns Hopkins University a $695,018 Project Grant effective August 1, 2025, through July 31, 2030, to conduct research on the regulation of retinal ganglion cell regeneration through Müller glia (MG) cell function. The award supports a five-year investigation into how MG cells function as injury-responsive stem cells to enable retinal regeneration, with the ultimate goal...
- Federal Grant Award Summary Baylor College of Medicine received a $1.6 million project grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 30, 2025, with completion scheduled for September 29, 2028. The research investigates the molecular mechanisms governing Muller glial cell (MGC) reprogramming and proliferation through modulation of the Hippo and Wnt signaling pathways. The project aims to identify cellular and molecular strategies to...
- Federal Grant Award Summary The University of California, San Francisco received a $130,182 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) for the period April 1, 2026 through March 31, 2028. This research project focuses on identifying and characterizing neurons in the adult and developing primary visual cortex (V1) that receive bottom-up sensory inputs from the thalamus or top-down predictive inputs from higher visual areas. The research...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant of $545,948 under the Vision Research program (CFDA 93.867) to advance understanding of glaucoma pathophysiology. The award, effective April 1, 2026 through March 31, 2030, supports research investigating the role of reactive astrocytes in glaucoma progression and retinal ganglion cell (RGC) survival. The research aims to move beyond traditional neurocentric...
The National Eye Institute (NEI) awarded $255,340 through the Vision Research program (CFDA 93.867) to The Regents of the University of California, San Francisco for a five-year project (May 1, 2026 – April 30, 2031) focused on understanding and regenerating retinal ganglion cells in the vertebrate retina. This research addresses glaucoma, which affects over four million Americans and represents the second leading cause of irreversible blindness globally. The primary deliverables include scientific research aimed at characterizing gene regulatory networks that direct retinal ganglion cell differentiation during development and generating evidence-based strategies for regenerating retinal ganglion cells from dormant progenitor cells in the adult retina. The research program employs advanced experimental techniques to investigate the role of transcription factor POU2F2 in retinal ganglion cell development through conditional gene deletion and gain-of-function studies using in vivo electroporation of postnatal progenitors. The candidate will acquire specialized expertise in retinal development and regeneration to enhance the scientific rigor of the research program. Research products will contribute to understanding mechanisms for restoring vision in patients with advanced glaucoma who have experienced irreversible retinal ganglion cell loss despite current pharmacological and surgical interventions targeting intraocular pressure reduction.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $255.3k | 4/16/26 |