Project Grant R01EY039360
- The National Eye Institute awarded The University of Texas Southwestern Medical Center $456,500 on July 1, 2026, under the Vision Research program (CFDA 93.867, Assistance Listing) for spatial molecular profiling of optic nerve injury and assessment of extracellular matrix (ECM) proteins. The research examines why regenerated retinal ganglion cell (RGC) axons fail to reach the brain after optic nerve injury, instead following circuitous pathways within fibrotic scars—a phenomenon the...
- The National Eye Institute, a division of the Department of Health and Human Services National Institutes of Health, awarded $451,871 to the University of Texas at Austin on September 1, 2026, under the Vision Research program (CFDA 93.867, Assistance Listing program R01EY038362). The award funds research on anticipation and integration in the primate visual system, specifically investigating how temporal prediction shapes neural computation and visual representation. The project will test the...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The Methodist Hospital Research Institute $224,100 on June 1, 2026, under the Vision Research program (CFDA 93.867) to investigate how direct connections between primary visual cortex and prefrontal cortex interact with the pulvinar nucleus of the thalamus to shape visual perception and visually-guided decision-making in nonhuman primates. The recipient will employ focused...
- The National Eye Institute, a component of the Department of Health and Human Services National Institutes of Health, awarded $513,299 to the University of Texas at Arlington on September 1, 2026, under the Vision Research program (CFDA 93.867) for a Project Grant supporting fundamental research in transcriptional regulation underlying ocular health and disease. The award funds development of TREX, a variational Bayesian framework designed to identify tissue-specific transcriptional regulators...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The University of Chicago $929,806 on September 30, 2025, under the Vision Research program (CFDA 93.867). The award funds research into synaptic development of the retinogeniculate pathway—the neural circuit connecting the eyes to the brain—with investigation focused on how neurons form correct connections during childhood development and how visual experience shapes that...
- The National Eye Institute awarded the University of California, Berkeley $153,560 on February 18, 2027, under the Vision Research program (CFDA 93.867) to investigate the ultrastructural development and regeneration of nodes of Ranvier in the mouse optic nerve. The project applies cryo-electron tomography (cryo-ET) with laser phase plate enhancement to visualize nodal protein complexes in situ and understand how ion channel scaffolding proteins establish and maintain rapid neural signaling. Aim...
- The National Eye Institute, a bureau of the Department of Health and Human Services National Institutes of Health, awarded $497,740 to the University of Illinois on April 1, 2026, under the Vision Research program (CFDA 93.867) to fund research into neuro-epithelial interactions in corneal disease and repair, with Principal Investigator Elmira Jalilian. The project investigates how corneal epithelial cells and trigeminal nerve fibers (the V1 ophthalmic branch) interact to maintain corneal...
- The National Institutes of Health National Eye Institute awarded the University of Connecticut Health Center $416,250 on April 15, 2026, under the Vision Research program (CFDA 93.867) to investigate NFE2L3-regulated mechanisms of retinal ganglion cell neuroprotection and optic nerve axon regeneration. The research examines molecular mechanisms through which the NFE2L3 protein regulates regeneration of damaged optic nerve axons in retinal ganglion cells. The project uses established animal...
- The National Eye Institute awarded The Trustees of The University of Pennsylvania $719,199 on August 5, 2026, under the Vision Research program (CFDA 93.867) to advance understanding of retinal ganglion cell and optic nerve regeneration following injury and optic neuropathies. The research will employ single-cell CRISPR screening (perturb-seq) to systematically identify genes and gene combinations whose suppression most effectively promotes retinal ganglion cell and optic nerve regeneration...
- The National Eye Institute awarded The Regents of the University of California, doing business as University of California, Berkeley, $383,583 on September 15, 2025, under the Vision Research program (CFDA 93.867) to conduct research on the role and regulation of optic nerve microglia in glaucomatous neuropathy. Work is performed in Berkeley, California through August 31, 2027. The funded research investigates how disease-associated microglia expressing CD74 markers in the myelinated optic nerve...
The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $2,271,828 to The University of Texas Southwestern Medical Center on September 1, 2026, under the Vision Research program (CFDA 93.867). The recipient will conduct research into the cellular and molecular mechanisms governing optic nerve myelin integrity, with emphasis on understanding how myelin whorls—multilayered degenerative myelin structures that appear in demyelinating optic nerve diseases such as optic neuritis and glaucoma—are generated and eliminated during optic nerve development. The research will employ a novel mouse line enabling selective labeling of newly formed oligodendrocytes and their myelin sheaths in the optic nerve to investigate the role of the transcription factor EB (TFEB) and autophagy-related pathways in myelin whorl clearance and myelin quality control within optic nerve oligodendrocytes. Work is performed in Dallas, Texas, with a period of performance from September 1, 2026, through August 31, 2030. This is a Project Grant, the standard assistance type for investigator-initiated biomedical research funded by NIH institutes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.3m | 8/26/26 |