Project Grant R01EY038322
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Johns Hopkins University a $695,018 Project Grant effective August 1, 2025, through July 31, 2030, to conduct research on the regulation of retinal ganglion cell regeneration through Müller glia (MG) cell function. The award supports a five-year investigation into how MG cells function as injury-responsive stem cells to enable retinal regeneration, with the ultimate goal...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Johns Hopkins University a Vision Research grant (CFDA 93.867) totaling $173,286.17 to evaluate the regenerative potential of human retinal ganglion cells (RGCs). This project, which commenced June 1, 2025, addresses a critical barrier to vision restoration by investigating whether intrinsic factors regulating RGC survival and neurite outgrowth can be modulated to promote axonal regeneration and optic nerve...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a three-year Project Grant totaling $2,674,763 to Centre Hospitalier De L'Université De Montréal (CHUM) beginning September 30, 2025, with completion targeted for September 29, 2028. This award funds research investigating interpericyte tunneling nanotubes (IPTNTs) as therapeutic targets for glaucoma treatment and vision restoration. The research will generate empirical findings...
- Federal Grant Award Summary The University of Washington received a $458,288 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2026 through February 28, 2030. This five-year research initiative will advance regenerative therapies for retinal neuron loss by investigating methods to stimulate Müller glia cells to regenerate damaged retinal neurons in humans and non-human primates. The project will deliver research products...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant of $545,948 under the Vision Research program (CFDA 93.867) to advance understanding of glaucoma pathophysiology. The award, effective April 1, 2026 through March 31, 2030, supports research investigating the role of reactive astrocytes in glaucoma progression and retinal ganglion cell (RGC) survival. The research aims to move beyond traditional neurocentric...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $255,340 through the Vision Research program (CFDA 93.867) to The Regents of the University of California, San Francisco for a five-year project (May 1, 2026 – April 30, 2031) focused on understanding and regenerating retinal ganglion cells in the vertebrate retina. This research addresses glaucoma, which affects over four million Americans and represents the second leading cause of irreversible blindness globally. The...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $144,618 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through March 31, 2028. The grant funds research investigating fucosylation as a mediator of limbal stem cell (LSC) viability. The research focuses on understanding how fucose, a monosaccharide component of the cell surface glycocalyx, influences the survival of limbal stem...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $497,740 to the University of Illinois (Chicago, IL) under the Vision Research program (CFDA 93.867), effective April 1, 2026, through March 31, 2031. Under the direction of Principal Investigator Elmira Jalilian, this research project will generate scientific findings and empirical data examining neuro-epithelial interactions in corneal disease and repair, with particular focus on how corneal nerves...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded University of California, Irvine $179,964 under the Vision Research program (CFDA 93.867) on March 1, 2025, for a project grant extending through July 10, 2029. The project focuses on developing deep learning-based biomarkers for optic neuropathies using retinal Optical Coherence Tomography (OCT) imaging analysis. The research will employ advanced computational techniques, including deep generative models, neural field image...
The University of Connecticut Health Center received a $416,250 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), with an award date of April 15, 2026 and a completion date of March 31, 2030. This research project investigates the molecular mechanisms through which the NFE2L3 protein regulates axon regeneration in retinal ganglion cells (RGCs) and optic nerve recovery following injury. The primary deliverables include empirical findings on how NFE2L3 activates RGCs' intrinsic regenerative capacity, identification of which RGC populations respond to NFE2L3-mediated regeneration, and characterization of the molecular pathways governing long-distance axon growth through the optic nerve. The research utilizes established animal models and state-of-the-art molecular technologies to understand neuroprotective mechanisms that could restore visual function after optic nerve injuries caused by trauma, ischemia, or glaucoma. The expected outcome is the development of a novel therapeutic approach applicable to various optic neuropathies, addressing the current gap in regenerative treatments for central nervous system (CNS) axonal injuries. Research will be conducted at the University of Connecticut Health Center's Farmington, Connecticut facility.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $416.3k | 4/10/26 |