Project Grant R01EY038765
- The National Eye Institute awarded The Johns Hopkins University $682,679 under the Vision Research program (CFDA 93.867) on July 1, 2026, to identify drivers of retinal ganglion cell differentiation from endogenous stem cells. The research aims to characterize how retinal ganglion cells regenerate in zebrafish, identify the signals that regulate this regeneration, and discover factors that drive regeneration independently of cell loss. Retinal ganglion cells are the sole neurons capable of...
- The National Eye Institute awarded The Trustees of The University of Pennsylvania $719,199 on August 5, 2026, under the Vision Research program (CFDA 93.867) to advance understanding of retinal ganglion cell and optic nerve regeneration following injury and optic neuropathies. The research will employ single-cell CRISPR screening (perturb-seq) to systematically identify genes and gene combinations whose suppression most effectively promotes retinal ganglion cell and optic nerve regeneration...
- The National Eye Institute awarded the University of California, San Diego $701,576 on July 1, 2026, under the Vision Research program (CFDA 93.867) to explore retinal ganglion cell endogenous repair after injury using engineered human pluripotent stem cells. The research uses human pluripotent stem cell-derived 3D retinal organoids as a model to investigate glia-to-neuron repair mechanisms in the retina. Work focuses on how transcription factors enable Müller glia to respond to injury and...
- The National Eye Institute awarded The Johns Hopkins University $776,269 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop and externally validate critical elements of a clinical decision support system (CDSS) that optimizes treatment selection for glaucoma patients experiencing rapid visual field deterioration. The project addresses a treatment gap: randomized controlled trials demonstrate that non-medical interventions (surgery or laser trabeculoplasty) produce less...
- The National Eye Institute awarded The Johns Hopkins University $427,504 on July 1, 2026, under the Vision Research program (CFDA 93.867) to develop BLAB-SEQ, a non-toxic, transgene-based method that combines fluorescent birth dating with single-cell RNA sequencing to determine birth dates and transcriptomic profiles of neuronal subtypes in human organoids. The project will integrate birth-labeled sequencing with multiomics analysis to directly link neuronal birth timing and fate...
- The National Eye Institute awarded Baylor College of Medicine $1.6 million on September 30, 2025, under the Vision Research program (CFDA 93.867) to conduct basic research on Hippo and Wnt pathway regulation of mammalian Müller glial cell reprogramming and proliferation as a strategy for retinal regeneration in glaucoma, macular degeneration, diabetic retinopathy, and traumatic retinal injury. The research employs genetic loss- and gain-of-function experiments, fate mapping, and single-cell...
- The National Eye Institute awarded The Regents of the University of California, San Francisco $127,180 on July 1, 2026, under the Vision Research program (CFDA 93.867) to conduct research on perivascular retinal ganglion cells in shaping vascular architecture and neurovascular resilience. The research investigates how a specialized subset of retinal ganglion cells (RGCs) marked by FAM19A4/NTS guide formation and maintenance of the retina's three-dimensional vascular architecture through...
- The National Eye Institute awarded The Regents of the University of California, San Francisco $255,340 on May 1, 2026, under the Vision Research program (CFDA 93.867) to support development and regeneration of retinal ganglion cells in the vertebrate retina. The award funds a career development project investigating gene regulatory networks that direct retinal ganglion cell differentiation during development and applying those insights to regenerate retinal ganglion cells from dormant progenitor...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $100,228 on December 1, 2026, under the Vision Research program (CFDA 93.867). The recipient will conduct preclinical research on autologous transplantation of genetically modified induced pluripotent stem cells (iPSCs) to treat autosomal dominant retinal disorders, specifically RPE65 D477G mutations causing retinitis...
- The National Eye Institute awarded the University of Pittsburgh $433,324 under the Vision Research program (CFDA 93.867) on September 1, 2026, to develop next-generation microfluidic platforms for high-throughput screening of axon growth-promoting compounds as potential regeneration therapies for glaucoma and optic neuropathies. The project focuses on addressing limitations in conventional axon growth assays by engineering microfluidic devices that enable defined chemoattractant gradients,...
The National Eye Institute awarded The Johns Hopkins University $698,999 on July 1, 2026, under the Vision Research program (CFDA 93.867) to conduct research on mechanisms of functional retinal engraftment by transplanted retinal ganglion cells for optic neuropathies including glaucoma. The project addresses the death of retinal ganglion cells (RGCs), which transmit visual information from the eye to the brain. While existing treatments slow vision loss in some progressive optic neuropathies, no treatments restore sight lost to these neurodegenerative conditions. Unlike some cold-blooded vertebrates, mammals lack the capacity for RGC regeneration. The research overcomes prior challenges to transplantation of stem cell-derived RGCs by developing methods to disrupt the retina's internal limiting membrane, which improves survival, engraftment, and synaptic connectivity of human RGCs in multiple species. The project goal is to augment long-term donor RGC survival and establish physiologic connectivity to functionally relevant inner retinal circuits by transiently suppressing a key cell-intrinsic pathway involved in neuronal maturation. Preliminary data show that deletion of the PTEN gene dramatically increases donor RGC survival and dendritogenesis early following transplantation. Work is performed in Baltimore, Maryland. The period of performance runs through March 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $699.0k | 8/4/26 |