Project Grant R21EY037056
Award Date
5/1/25
Completion Date
4/30/28
Dollars Obligated
$443K
Federal Agency
National Eye Institute
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Davis, CA, USA
Similar Awards
The National Eye Institute (NEI) awarded a 5-year, $2,166,307 Project Grant under the Vision Research program (CFDA 93.867) to the Scripps Research Institute in La Jolla, CA. The grant funds research to investigate the anti-inflammatory mechanisms of calorie restriction in the aged lacrimal gland, with the goal of developing interventions for age-associated lacrimal gland inflammation and dry eye disease. The research will employ spatial transcriptomics, immunostaining, flow cytometry, and...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides funding of $294,662 to Proteris Biotech, Inc. to support research on using the protein Clusterin (CLU) to treat ocular surface disease and dry eye. The project aims to determine whether CLU can protect the ocular surface epithelia from damage and also have an anti-inflammatory effect in dry eye disease. Recombinant human CLU will be tested for efficacy in a mouse...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), is focused on analyzing sex- and race-specific differences in tear microRNAs (miRNAs) and proteins in patients with dry eye disease. The total funding amount is $1,576,417.00, and the award period runs from July 1, 2024 to April 30, 2028. The primary objectives are to discover biomarkers in tear fluid that can distinguish dry eye disease subtypes and correlate with clinical...
This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, supports the development of an optimized nerve growth factor (NGF) therapeutic for the treatment of dry eye disease (DED). The $730,000 award will fund a Phase I study to evaluate the efficacy and mechanism of action of the company's proprietary NGF mutein, HC201, in a mouse model of corneal nerve injury. The goal is to determine whether topical treatment with HC201 can...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will fund a research project titled "Understanding Barriers to Accessing Eye Care and Their Impacts on the Prognosis of Dry Eye Disease". The $383,000 award, with a project period from September 30, 2024 to August 31, 2026, will be led by the University of Colorado-Denver as the prime grantee. The University of Michigan has been awarded a $146,771 sub-grant...
This Project Grant award from the National Eye Institute (NEI) under CFDA Program 93.867 "Vision Research" provides $251,250 to support research to characterize the pathobiology of autoimmune meibomian gland dysfunction (MGD) and its link to dry eye disease. The primary awardee is Baylor College of Medicine, which will collaborate with the University of Houston College of Optometry as a sub-recipient under this award. The research aims to investigate the role of autoreactive CD4+ T...
This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) will provide $1,330,026 to The Trustees of the University of Pennsylvania to develop two new mouse models of geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD). The goal is to evaluate the potential of the novel antioxidant deuterated docosahexaenoic acid (D-DHA) to protect the retinal pigment epithelium (RPE) from GA formation and...
The National Eye Institute (NEI) awarded a $441,822 Project Grant (CFDA 93.867 - Vision Research) to The Johns Hopkins University to investigate the functional and therapeutic roles of the Hedgehog signaling pathway in meibomian gland development, renewal, and dysfunction. The research aims to understand the underlying mechanisms of meibomian gland disease, a leading cause of dry eye disease, and explore novel therapeutic approaches by targeting the Hedgehog pathway. The research will be...
This $615,979 Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate a promising peptide-based combination therapy for restoring structure and function in the diabetic cornea. The key objectives are to: 1) establish the therapeutic role of TB4 and VIP as a combination treatment against diabetes-induced corneal complications; and 2) elucidate the DDR-TRP axis, a novel pathway responsive to hyperglycemic...
The National Eye Institute (NEI) awarded a $291,375 Project Grant (CFDA 93.867 - Vision Research) to the University of Connecticut Health Center (UCHC) to develop a novel mouse model for spontaneous and age-related choroidal neovascularization (CNV). The goal is to create a chronic CNV model that mimics the pathophysiological conditions associated with the wet form of age-related macular degeneration (AMD), a leading cause of blindness. The project will systematically characterize the onset...