Project Grant R00EY034550
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $475,442 to the University of California, Los Angeles (UCLA) to conduct research focused on understanding the mechanisms underlying the ingestion of photoreceptor outer segment tips by the retinal pigment epithelium (RPE). The research aims to investigate the dynamic actin polymerization and trogocytosis process involved in this essential cellular function, as well as the daily timing of outer...
- This federal Project Grant award for $574,158.00 was provided by the National Eye Institute (CFDA 93.867 Vision Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The award supports research to investigate the role of melanopsin, a light-sensitive protein, in the renewal of photoreceptor outer segments - a critical homeostatic process for maintaining visual function. The research aims to expand on preliminary findings demonstrating melanopsin's...
- This $240,750 federal Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) aims to investigate the role of neural-glial-vascular signaling in the development of the eye's vasculature. The research has two main objectives: 1) Characterizing vasculature development and how it is altered in mice with modified retinal waves, using quantitative approaches and live imaging, and 2) Establishing the maturation of the glial-vascular unit through immunofluorescence...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $431,750 Project Grant to the University of Louisville to study the role of neurexin proteins in retinal structure and function. The grant, effective from September 1, 2025 to August 31, 2027, aims to 1) determine the function of three neurexin genes and their isoform-specific expression patterns within the retina, and 2) characterize the cell-type-specific expression of neurexin isoforms...
- The National Eye Institute (NEI) awarded a $437,310 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Rochester to conduct research on the molecular and physiological mechanisms of inner retinal remodeling in retinal degeneration. The research aims to elucidate the mechanisms behind genetic, morphological, and physiological changes in retinal ganglion cells that lead to decreased signal-to-noise ratio and corruption of retinal circuits, with the...
- The National Eye Institute (NEI) awarded a $673,747 Project Grant to New York University (NYU) for the "Visible-to-Near-Infrared Spanning Optical Coherence Tomography for Retinal Imaging at the Half-Micron Scale" research project under the NEI's Vision Research program (CFDA 93.867). The grant aims to develop advanced optical coherence tomography (OCT) techniques to enable more accurate in vivo measurement and localization of macular pigments and retinal pigment epithelium melanosomes,...
- The University of Massachusetts Boston received a $435,052 project grant from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to conduct research on the molecular mechanisms that control the spatially precise expression patterns of photoreceptor subtypes for color vision. The long-term goal is to use the Drosophila melanogaster retina as a model to decipher the cis-regulatory mechanisms and identify conserved trans-acting factors that specify...
- This National Eye Institute Project Grant award, under the Vision Research federal grant program (CFDA 93.867), provides $248,909.00 to Emory University to conduct research focused on understanding changes to metabolism during the progression of photoreceptor degeneration in retinitis pigmentosa (RP). The key goals are to determine how the rate of metabolism changes with RP disease stage and identify metabolites that increase oxygen consumption by the retinal pigment epithelium (RPE)-choroid....
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- This federal Project Grant award of $624,230 was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to the University of California, Los Angeles (UCLA) starting on May 1, 2025. The grant will support research to investigate changes in rod photoreceptor function and connectivity in the retina during the progression of retinal degeneration, with the goal of understanding how the retina maintains visual processing during cell loss. The...
The federal Project Grant award of $249,000.00 from the National Eye Institute (NEI) under the Vision Research grant program (CFDA 93.867) will support research at the University of Maryland, Baltimore (UMB) to elucidate unique spectral-temporal fluorescence signatures to determine stratification and redistribution of intracellular retinal pigment epithelial (RPE) cell pigment granules. The research aims to provide fundamental insight into the connection between retinal pigment redistribution dynamics and the functional status of RPE cells, which is critical for understanding age-related macular degeneration affecting over 2 million Americans. The project will run from September 30, 2025 to August 31, 2028 and involve developing new in vivo imaging technologies to map the distribution of retinal pigments in the living human eye and track pigment granule redistribution and modification dynamics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 9/17/25 |