Project Grant R01EY036135
- Federal Grant Award Summary The University of California, Irvine received a $431,750 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2026, through April 30, 2028. The award funds exploratory research investigating novel mechanisms of obstructive meibomian gland dysfunction (O-MGD), a condition characterized by blocked meibomian glands leading to dry eye disease. The research will produce scientific findings and technical...
- Federal Grant Award Summary The University of Missouri System received a $422,199 project grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) for the period July 1, 2025 through June 30, 2027. This research initiative focuses on identifying and targeting sex hormone receptors as a novel therapeutic approach to treat Meibomian Gland Dysfunction (MGD), the leading cause of dry eye disease worldwide. The project will investigate the crosstalk regulation...
- This $624,743 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports a four-year research initiative at UC Berkeley examining the function and regulation of prostaglandin D2 (PGD2) and DP receptor signaling in retinal health and neurodegeneration. The research will deliver empirical findings on the physiological and neuroprotective roles of PGD2 in the retina, building upon preliminary discoveries that PGD2 is constitutively expressed...
- This Project Grant award for $383,000 from the National Eye Institute (CFDA 93.867 - Vision Research) aims to identify social determinants of health (SDOH) indicators associated with disparities in the diagnosis, management, and prognosis of dry eye disease. The project will leverage electronic health record data from a single-center and multi-center (Sight Outcomes Research Collaborative) datasets to build prognostic models that account for individual and structural barriers to accessing eye...
- This $403,750 Project Grant from the National Eye Institute of the Department of Health and Human Services will fund research into the regulation of retinal microvascular stiffness by the matricellular protein CCN1 and its implications for ischemic retinopathy. The awardee, the Research Foundation for the State University of New York on behalf of SUNY Downstate Health Sciences University, will investigate the effects of CCN1 on the mechanical properties of retinal microvascular endothelial cells...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Methodist Hospital Research Institute a $1,029,472 Project Grant under the Vision Research program (CFDA 93.867) to develop innovative cell therapy for age-related macular degeneration (AMD), with performance occurring in Houston, Texas from May 1, 2026 through April 30, 2028. The research delivers scientific investigation into mitochondrial transplantation as a therapeutic intervention, specifically through the...
- Summary of Cooperative Agreement Award The University of Rochester received a $744,451 Cooperative Agreement from the National Eye Institute under the Vision Research program (CFDA 93.867), awarded March 17, 2026, with completion targeted for February 28, 2027. This award supports the development of small molecule Proteolysis-Targeting Chimeras (PROTACs) designed to inhibit secretory phospholipase A2-IIA (sPLA2-IIA) as a novel therapeutic approach for age-related macular degeneration (AMD) and...
- Federal Project Grant Award Summary N'waii Inc. received a $697,600 Project Grant from the National Eye Institute (NIH) under the Vision Research program (CFDA 93.867), awarded on September 30, 2025, with completion anticipated by September 29, 2026. The award supports the development of a first-in-class mitochondrially targeted antioxidant therapeutic candidate designed to address dry eye disease (DED), a condition affecting approximately 20% of the global adult population. The company's...
- This $460,625 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to Yale University. The grant will fund research to investigate the cellular and synaptic mechanisms underlying changes in retinal ganglion cell (RGC) activity following optic nerve injuries in mouse models of glaucoma. Specifically, the project aims to (1) determine the underlying mechanisms for altered RGC activity after increased intraocular pressure or...
- The National Eye Institute (NEI) awarded $764,881 to the University of Colorado-Denver under the Vision Research program (CFDA 93.867) on September 15, 2025, to support a two-year research project investigating the role of advanced glycation end products (AGEs) in primary open-angle glaucoma (POAG). The project will generate fundamental research findings and preclinical data on how AGEs accumulate in trabecular meshwork (TM) tissues and contribute to elevated intraocular pressure and optic nerve...
FUNCTIONAL AND THERAPEUTIC ROLES OF THE HEDGEHOG SIGNALING IN MEIBOMIAN GLANDS DEVELOPMENT, RENEWAL AND DYSFUNCTION - MEIBOMIAN GLAND DISEASE (MGD) IS CONSIDERED THE LEADING CAUSE OF DRY EYE DISEASE, A COMMON MULTIFACTORIAL DISEASE WITH A GLOBAL PREVALENCE OF 5 TO 50% AND A MAJOR AGE-RELATED DISEASE OF THE OCULAR SURFACE. MEIBOMIAN GLANDS (MG) ARE MODIFIED SEBACEOUS GLANDS THAT LINE THE MARGIN OF THE EYELID, SECRETE LIPIDS AT THE OCULAR SURFACE, AND PARTICIPATE IN INCREASING THE STABILITY OF THE TEAR FILM. MGS ARE HOLOCRINE GLANDS, WHICH IMPLIES THEY ARE CONTINUALLY RENEWED SINCE THEY DELIVER THEIR SECRETORY PRODUCT, CALLED MEIBUM, BY APOPTOSIS. THUS, REGULATION OF MG STEM CELLS IS CRUCIAL TO ENSURE THE PROPER FUNCTION OF MGS. WITH THE AGING PROCESS OR DISEASE CONDITION, MGS CAN PROGRESSIVELY LOSE THEIR RENEWAL CAPABILITY AND REGRESS TO AN ATROPHIC STATE. THE PATHOGENESIS OF MGD AND THE MECHANISMS BY WHICH AGING AFFECTS THE RENEWAL PROCESS REMAIN LARGELY UNKNOWN. TREATMENT OPTIONS ARE CURRENTLY LIMITED MAINLY DUE TO THE LACK OF CLEAR THERAPEUTIC TARGETS AND EFFECTIVE DRUG DELIVERY STRATEGIES TARGETING THE TISSUE OF MGS. THUS, THERE IS A CRITICAL NEED TO UNDERSTAND SIGNALING CASCADES UNDERLYING THE RENEWAL PROCESS OF THE MG THAT CAN BE PHARMACOLOGICALLY TARGETED TO TREAT MGD. OUR RECENT ADVANCES, WITH THE AID OF AN NIH/NEI R21 (EY030661), HAVE LED US TO DISCOVER A NOVEL ROLE OF THE PRIMARY CILIUM IN MG DEVELOPMENT AND MAINTENANCE SUGGESTING A ROLE OF HH IN THE THIS PROCESS. THE HEDGEHOG (HH) PATHWAY PLAYS A FUNDAMENTAL ROLE IN TISSUE DEVELOPMENT, HOMEOSTASIS, AND REPAIR, INCLUDING ADULT STEM CELL MAINTENANCE. TO DETERMINE THE THERAPEUTIC POTENTIAL OF TARGETING THE HH PATHWAY TO TREAT MGD, WE WILL INVESTIGATE ITS ROLE IN MG DEVELOPMENT, MAINTENANCE, AND RENEWAL AND TRACE THE CELL LINEAGE OF HH-RESPONSIVE CELLS INVOLVED IN MG HOMEOSTASIS. WE WILL TARGET THE HH PATHWAY IN MICE USING GENETIC AND PHARMACOLOGICAL HH MODULATORS TO IMPROVE AGE-RELATED MGD. IF SUCCESSFUL, THE OUTCOME OF THIS WORK WILL REVEAL MECHANISTIC INSIGHTS INTO MG RENEWAL AND DEFINE A NOVEL PARADIGM FOR HOW TO APPROACH NOVEL TREATMENT STRATEGIES FOR MGD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $428.9k | 8/4/25 | ||
| Not listed | $441.8k | 6/20/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
2006650089S | The University Of Texas Southwestern Medical Center | Project Grant R01EY036135 | $77.7k | 1/22/26 |