Project Grant R56EY035651
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- This federal Project Grant award of $234,000.00 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to enhance stem cell restoration of intraocular pressure (IOP) homeostasis through senolytic treatments. The key goals are to study how senescent trabecular meshwork (TM) cells in glaucoma patients affect IOP regulation, and to explore whether clearing these senescent cells using senolytic drugs can improve the effectiveness of...
- This $439,016 federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) aims to provide initial proof-of-concept for a novel therapeutic approach to glaucoma. The goal is to target the progressive TGFβ2-associated aqueous outflow pathway pathology in a feline model of early onset glaucoma. The project involves optimizing viral vector-mediated transduction of feline trabecular meshwork cells to suppress pathologic TGFβ2 signaling, which contributes to increased...
- This Project Grant award of $568,122.00, provided by the National Eye Institute (CFDA 93.867 - Vision Research), supports research at Baylor College of Medicine to unequivocally confirm the contribution of the neurovascular unit to glaucoma pathogenesis and identify endothelial cell-specific ligands with potential for neuroprotective therapy. The research aims to globally map ligands binding to ocular hypertension and healthy retinal cells, systematically identifying ocular...
- This $417,162 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research on using optical techniques to detect early signs of glaucoma, the leading cause of irreversible blindness worldwide. The University of Houston System, the grantee, will conduct research to determine if changes in the birefringence (optical properties) of the lamina cribrosa and posterior eye structures can serve as sensitive early indicators of glaucoma before structural damage...
- The National Eye Institute (NEI) awarded a $451,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Regents of the University of California, San Francisco (UCSF) to conduct a multimodal characterization of a novel inherited mouse model of glaucoma. The research aims to evaluate structural and functional changes in the mouse model, including axonal degeneration, retinal ganglion cell loss, dendritic changes, and neuroinflammatory responses. It will also identify...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $1,357,192 to The Trustees of the University of Pennsylvania to conduct research on the impact of WDR36 gene variants and p53 in glaucoma. The research aims to understand how WDR36 variants contribute to primary open-angle glaucoma (POAG) and whether retinal ganglion cells with these mutations respond to gene augmentation therapy. The study will utilize mouse models and human stem cell-derived...
- This $387,428 Project Grant from the National Eye Institute (CFDA 93.867 - Vision Research) aims to investigate fundamental mechanisms driving optic nerve sensitivity to elevated intraocular pressure, a major risk factor for optic nerve damage in glaucoma. The project will use 3D bioengineering tools, transgenic animal models, and ex vivo donor optic nerve head tissue to test the hypothesis that transient biomechanical strains prime optic nerve head astrocytes to develop greater glaucomatous...
- The Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports the development of an accurate, non-invasive, and automated 24-hour intraocular pressure (IOP) monitoring device. The overarching goal is to create a wearable IOP monitor that can improve the clinical management of glaucoma, the leading cause of irreversible blindness. The $713,964 award will fund research activities over a 5-year period from March 2025 to February 2030 at the University of California,...
- This $1,620,537 federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at Northwestern University to model aqueous humor outflow and develop a digital twin of the anterior eye to improve the understanding and treatment of glaucoma. The project aims to enhance minimally invasive glaucoma surgery (MIGS) efficacy by better characterizing the circumferential anatomy and pathophysiology of aqueous humor outflow, which currently limits the...
This federal Project Grant award of $764,881 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to investigate the role of advanced glycation end products (AGEs) in primary open-angle glaucoma (POAG). The overarching hypothesis is that the accumulation of AGEs in the trabecular meshwork promotes extracellular matrix remodeling and cell dysfunction, leading to increased outflow resistance and elevated intraocular pressure in POAG. The research project has two specific aims: 1) To test whether AGEs in the trabecular meshwork lead to extracellular matrix remodeling and cell dysfunction, and 2) To investigate whether increasing AGE levels in the trabecular meshwork contributes to increased outflow resistance and elevated intraocular pressure. The project will be conducted by the University of Colorado-Denver and is expected to run from September 2025 to September 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $764.9k | 9/3/25 |