Project Grant R21EY038406
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $1,488,864 under the Vision Research program (CFDA 93.867), effective September 1, 2025 through June 30, 2028. The grant supports research investigating epigenetic regulation of the meibomian gland in homeostasis and aging, with the objective of identifying therapeutic targets for evaporative dry eye disease (EDED). The research focuses on histone deacetylases...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $495,229 to Augusta University Research Institute, Inc. for a project addressing dry eye disease (DED) molecular subtyping. Initiated April 1, 2026, and concluding February 28, 2029, this project delivers advanced diagnostic and research infrastructure products designed to improve DED management through precision medicine approaches. The primary deliverables include: (1)...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded a $624,743 Vision Research (CFDA 93.867) Project Grant to the University of California, Berkeley, effective May 1, 2026 through April 30, 2030. This award funds investigative research examining the function and regulation of constitutive prostaglandin D2 (PGD2) and DP receptor signaling in retinal health and neurodegeneration. The research will employ complementary methodologies including single-cell and bulk RNA...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $255,722 Project Grant to the University of California, Berkeley effective September 15, 2025, with a completion date of August 31, 2027. This award funds research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The research will deliver scientific findings examining how lipoxin B4 (LXB4)—an endogenous neuroprotective...
- Federal Grant Award Summary The University of Missouri System received a $422,199 project grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) for the period July 1, 2025 through June 30, 2027. This research initiative focuses on identifying and targeting sex hormone receptors as a novel therapeutic approach to treat Meibomian Gland Dysfunction (MGD), the leading cause of dry eye disease worldwide. The project will investigate the crosstalk regulation...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded University of California, Irvine $179,964 under the Vision Research program (CFDA 93.867) on March 1, 2025, for a project grant extending through July 10, 2029. The project focuses on developing deep learning-based biomarkers for optic neuropathies using retinal Optical Coherence Tomography (OCT) imaging analysis. The research will employ advanced computational techniques, including deep generative models, neural field image...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $128,610 Project Grant to the University of California, San Diego, effective December 1, 2025, with completion targeted for May 18, 2029. This research initiative focuses on elucidating the role of thousand and one (TAO) kinases in retinal ganglion cell (RGC) death, with the objective of developing complementary therapeutic strategies to mitigate axon injury signaling in...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded Doheny Eye Institute a $3.05M Vision Research (CFDA 93.867) Project Grant effective September 1, 2025, through August 31, 2028, to investigate the mechanobiology of retinal vascular inflammation and degeneration in diabetic retinopathy (DR). The research will generate scientific findings addressing early-stage DR pathogenesis, which currently represents the leading cause of vision loss in the working-age population. The...
The National Eye Institute (NEI) awarded a $431,750 Project Grant to the University of California, Irvine under the Vision Research program (CFDA 93.867) for the period May 1, 2026 through April 30, 2028. This award funds exploratory research investigating novel mechanisms underlying obstructive meibomian gland dysfunction (O-MGD), a condition characterized by altered meibum lipid synthesis that leads to duct dilation and dry eye disease. The research will produce empirical findings regarding molecular mechanisms controlling meibocyte differentiation and the stepwise expression of meibum lipid synthesis enzymes. The primary deliverables include confirmation that human meibomian gland epithelial cell (HMGEC) organoids recapitulate acinar development and sequential differentiation programs, identification of molecular mechanisms controlling meibocyte differentiation, determination of whether conditional knockouts induce an obstructive MGD phenotype, and establishment that altered meibum quality directly initiates psoriasis-like meibomian gland epithelial inflammatory disease. These research products will address critical knowledge gaps in meibomian gland function and contribute to understanding the pathophysiology of O-MGD and associated dry eye disease.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 5/4/26 |