Project Grant R01EY036920
- Federal Project Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $255,722 Project Grant to the University of California, Berkeley effective September 15, 2025, with a completion date of August 31, 2027. This award funds research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The research will deliver scientific findings examining how lipoxin B4 (LXB4)—an endogenous neuroprotective...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $481,500 Project Grant to the University of California, Berkeley effective September 1, 2025, through August 31, 2026, under the Vision Research program (CFDA 93.867). This research grant supports an investigation titled "A Role for Retinal Waves in Vascular Development," which aims to elucidate the signaling mechanisms between neurons, glial cells, and blood vessels during retinal development. The research...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded the University of California, Davis $423,767 under the Vision Research program (CFDA 93.867) for a two-year project period beginning June 1, 2025 and concluding May 31, 2027. The research project investigates the role of myeloid cells as mediators of glaucomatous axon degeneration and evaluates whether nicotinamide adenine dinucleotide (NAD+)-boosting interventions provide neuroprotection through anti-inflammatory...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $128,610 Project Grant to the University of California, San Diego, effective December 1, 2025, with completion targeted for May 18, 2029. This research initiative focuses on elucidating the role of thousand and one (TAO) kinases in retinal ganglion cell (RGC) death, with the objective of developing complementary therapeutic strategies to mitigate axon injury signaling in...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $2,143,860 to the University of California, Berkeley on August 11, 2025, for a five-year project extending through June 30, 2030. The project, "Mechanisms for Generative Vision in the Primate Ventral Stream," will deliver neuroscience research products investigating how the primate brain implements visual perception through analysis-by-synthesis—a cognitive...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $437,250 to the University of California, San Diego to develop an integrated bioprinting and optogenetics platform for evaluating neural activity in stem cell-derived retinal disease models. The award, effective September 1, 2025, through August 31, 2027, supports research aimed at creating a "visual-circuit-on-a-chip" by integrating three-dimensional (3D)...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $431,750 Project Grant to the University of California, Irvine under the Vision Research program (CFDA 93.867) for the period May 1, 2026 through April 30, 2028. This award funds exploratory research investigating novel mechanisms underlying obstructive meibomian gland dysfunction (O-MGD), a condition characterized by altered meibum lipid synthesis that leads to duct dilation and dry eye disease. The research will produce...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $255,340 to The Regents of the University of California, San Francisco for research on the development and regeneration of retinal ganglion cells in the vertebrate retina. The award, granted on May 1, 2026, with a completion date of April 30, 2031, supports fundamental research aimed at understanding gene regulatory networks that direct retinal ganglion cell differentiation during development and at...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $545,948 Project Grant to The Schepens Eye Research Institute, Inc., effective April 1, 2026, through March 31, 2030. The award funds research to advance understanding of reactive astrocytes in glaucoma pathogenesis, a leading cause of irreversible blindness worldwide. The research moves beyond traditional neurocentric approaches to examine non-neuronal cellular responses in...
The National Eye Institute (NEI) awarded a $624,743 Vision Research (CFDA 93.867) Project Grant to the University of California, Berkeley, effective May 1, 2026 through April 30, 2030. This award funds investigative research examining the function and regulation of constitutive prostaglandin D2 (PGD2) and DP receptor signaling in retinal health and neurodegeneration. The research will employ complementary methodologies including single-cell and bulk RNA sequencing, in situ hybridization, Western blot analysis, and immunohistochemistry to characterize PGD2 pathway expression patterns across retinal tissues and to evaluate the neuroprotective potential of PGD2 signaling in models of retinal ganglion cell degeneration. Given the therapeutic relevance of prostaglandins in ocular disease treatment—as evidenced by their current use in managing intraocular pressure, ocular allergies, pain, and inflammation—this research addresses a significant gap in understanding prostaglandin physiology specific to retinal tissue. The project will generate foundational scientific knowledge regarding PGD2's physiological role in the retina and its potential neuroprotective mechanisms, which may inform future therapeutic interventions for retinal degenerative diseases. Preliminary findings demonstrate that DP receptor agonists provide protection against glutamate-induced neuronal cell death, suggesting potential applications in conditions involving excitotoxic retinal damage. The research deliverables will comprise empirical findings, mechanistic data, and translational insights that advance the understanding of retinal neuroprotection and contribute to the NEI's mission of preventing and treating vision diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $624.7k | 4/24/26 |