This Project Grant award from the National Eye Institute (NEI), part of the Vision Research federal grant program (CFDA 93.867), will provide $753,959 to Baylor College of Medicine over the period of June 1, 2024 to May 31, 2029. The project aims to investigate the mechanistic connections between retinal ganglion cell (RGC) activity, resilience, and axon regeneration following traumatic injuries and optic neuropathies like glaucoma. The research will employ cutting-edge approaches to dissect the...
This $526,841 Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate the role of cyclic guanosine monophosphate (cGMP) signaling in glaucomatous neurodegeneration. The primary objectives are to determine how disrupted cGMP signaling affects retinal astrocyte-vascular networks, leading to retinal ganglion cell (RGC) metabolic stress and axon degeneration in glaucoma. The research will discern age- versus...
This federal Project Grant award from the National Eye Institute (NEI), under the CFDA 93.867 Vision Research Program, provides funding of $679,159 from May 1, 2025 to April 30, 2029 to The Schepens Eye Research Institute, Inc. to conduct research on in vivo epigenetic reprogramming of retinal ganglion cells in aging mice with glaucoma. The key objectives of this research project are to: (1) investigate the combined effects of aging and elevated intraocular pressure on the development of...
The National Eye Institute (NEI) awarded a $387,428 Project Grant under its Vision Research program (CFDA 93.867) to investigate mechanisms underlying optic nerve sensitivity to glaucomatous damage. The award, with a project period from March 1, 2025 to February 28, 2030, will support research conducted by The Research Foundation for the State University of New York, Upstate Medical Center. The research aims to: 1) Determine how optic nerve head astrocytes integrate transient biomechanical...
The National Eye Institute (NEI) awarded a $1,666,746 Project Grant (CFDA 93.867 - Vision Research) to The Leland Stanford Junior University to investigate how the expression of activated forms of calcium/calmodulin-dependent protein kinase II (CaMKII) can provide neuroprotection for retinal ganglion cells, while also potentially suppressing axon regeneration. The research project aims to derive strategies that promote retinal ganglion cell survival without preventing axon regeneration, which is...
This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is focused on investigating the role of neural activity in improving retinal ganglion cell (RGC) replacement therapies for glaucoma. The $132,597 grant aims to establish a model for manipulating host RGC neural activity to distinguish donor RGC activity and quantify functional integration with existing visual neural circuits. The research will explore how inhibiting host...
The National Eye Institute (NEI) awarded a $191,095 Project Grant (CFDA 93.867 Vision Research) to the University of North Texas Health Science Center (UNTHSC) to conduct research on glaucoma-related fibrosis and metabolic changes in the optic nerve head. The project aims to investigate how extracellular matrix signaling and mechanosensing in optic nerve head astrocytes and lamina cribrosa cells drive metabolic reprogramming, specifically prioritizing glutaminolysis, to promote a maladaptive...
The National Eye Institute (NEI) awarded a $227,265 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of California, Berkeley to map human retinal ganglion cell receptive fields in vivo at cellular resolution. The primary objective is to directly connect light stimulation of individual retinal photoreceptors to both the activity of retinal ganglion cells and the conscious percept of that activity. This work will be performed in the university's...
The National Eye Institute (NEI) awarded a $360,897 Project Grant (CFDA 93.867 - Vision Research) to Human Cell Co, a for-profit biotechnology research and development company located in Naperville, Illinois. The grant funding will support a Phase 1 study to determine whether combining topical administration of a novel nerve growth factor (NGF) mutein, HC201, with oral nicotinamide (NAM) supplementation can more effectively improve retinal ganglion cell (RGC) function compared to either...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) will support research at Stanford University to investigate the molecular, cellular, and transcriptional mechanisms that regulate reactive astrocyte behavior and its impact on retinal ganglion cell (RGC) survival in glaucoma. The $1,130,220 award, running from September 1, 2024 to April 30, 2029, will utilize novel AAV viral vectors to target optic nerve head astrocytes and Müller glia,...