Project Grant R01EB028532

The Stanford University received a three-year $2.83 million Project Grant from the Department of Health and Human Services National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant will support development of novel methods to dramatically reduce the cost of stem cell maintenance and increase the scale of organoid production for organ biofabrication applications. Specifically, the university will engineer growth factor-free human...

The Department of Health and Human Services' National Institutes of Health Office of the Director awarded the University of Texas at Austin a $2,708,214 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to develop a novel semi-autonomous surgeon-in-the-loop robotic bioprinting system. The system aims to enable in situ robotic bioprinting of human tissues and organs to simultaneously restore functional and cosmetic capabilities lost due to volumetric muscle loss injuries. A...

This $250,000 National Science Foundation Technology, Innovation, and Partnerships Project Grant supports the development of artificial substrates for growing human stem cells suitable for clinical applications at Oakland University from March 2023 to February 2025. The goal is to accelerate the potential benefits of using human pluripotent stem cells and their derivatives for treating and curing diseases by producing a synthetic substrate that supports growth of human pluripotent stem cells...

This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks...

This Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems Engineering Directorate will support $541,665 in research at The University of Iowa from October 2022 through September 2026. The grant aims to advance control of human induced pluripotent stem cell differentiation to retinal cells through genomic and microfluidic techniques. Researchers will develop genome-wide methods leveraging cell differentiation properties...

This four-year, $708,333 National Science Foundation project grant funds research at Georgia Tech Research Corporation to develop genetic and microfluidic technologies to direct the differentiation of human induced pluripotent stem cell-derived retinal organoids. Specifically, the researchers will apply genome-wide methods leveraging both cell differentiation and biomechanical properties to screen for pathways that regulate retinogenesis. Systems biology approaches will identify master...

This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and...

This $1,000,000 National Science Foundation project grant supports research at the University of Wisconsin-Madison to develop single cell-level programming of human induced pluripotent stem cell differentiation into chamber-specific cardiomyocytes. The goal is to generate cardiomyocytes from each chamber of the heart through precise control of Wnt and retinoic acid signaling at the single cell level via engineered genetic programs and superstructures. If successful, this approach could establish...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $600,000 Project Grant (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the Massachusetts Institute of Technology (MIT) to develop synthetic genetic controller circuits to precisely control the expression of key transcription factors and improve the efficiency and consistency of differentiating human induced pluripotent stem cells (hiPSCs) into hemogenic...

This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...