Project Grant 2225488
- This four-year, $708,333 National Science Foundation project grant funds research at Georgia Tech Research Corporation to develop genetic and microfluidic technologies to direct the differentiation of human induced pluripotent stem cell-derived retinal organoids. Specifically, the researchers will apply genome-wide methods leveraging both cell differentiation and biomechanical properties to screen for pathways that regulate retinogenesis. Systems biology approaches will identify master...
- This Project Grant award, provided by the National Eye Institute (CFDA 93.867 - Vision Research), is supporting research at The University of Iowa to enable the production of autologous (patient-derived) cell therapies for treating inherited retinal degenerative blindness. The $618,600 award, effective from March 1, 2025 to February 28, 2030, aims to address key challenges in the manufacturing of these personalized cell therapies, such as assessing retinal differentiation capacity and...
- This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and...
- Iowa State University received a $554,338 Project Grant award from the National Science Foundation on March 1, 2021 to support research titled "CAREER: REAL-TIME CONTROL OF CELL DIFFERENTIATION USING REINFORCEMENT LEARNING." The award will fund research through February 28, 2026 under the NSF's Engineering program (CFDA 47.041). The project aims to develop new reinforcement learning techniques to control stem cell differentiation in real time, with the goal of enabling on-demand and...
- This $500,000 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support the University of Notre Dame's research exploring the differentiation of stem cells into patterned blood vessel networks using hybrid memristor technology. Over a four-year period from October 2022 to September 2026, the University will engineer the first autonomous hybrid memory resistor and cell culture device to control human pluripotent stem cell differentiation into...
- This Project Grant award, valued at $999,745.00 and commencing on September 15, 2025, was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports the development of a novel "multiscale digital twin" framework to predict and control blood vessel growth and regeneration, with the goal of improving treatments for ischemic heart disease. The project will integrate molecular signaling dynamics,...
- This $125,805 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies that can identify and separate cells based on changes in the activity of naturally occurring light-emitting molecules like NAD(P)H. The goal is to enable label-free, rapid identification and purification of cell populations, with a focus on stem cells and their functional subsets. The research will create a single cell deposition module to...
- The National Science Foundation awarded $250,038 under the Integrative Activities program (CFDA 47.083) to The University of Iowa for a project grant completing in June 2027. The funding will support research to advance photo-manufacturing techniques for producing biomimetic materials and establish a community college to graduate school program called the "3D Printing in Bioengineering Rising Researcher Community." Specifically, the grantee will quantify the efficiency and...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) in the amount of $219,999 provides funding to the Regents of the University of Michigan to develop new approaches for precisely guiding stem cells to regenerate damaged tissues. The project, titled "CAREER: Engineering Instructive Niches to Precisely Guide Single Stem Cells," aims to create microenvironments that can direct fundamental stem cell processes like growth, division, and...
- This $750,000 Project Grant award, funded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074), supports the development of manufacturable 3D mammalian cell culture systems with integrated sensing technologies, focusing on neural organoids. The key objectives are to: (1) build and test conformal microelectrode arrays to interrogate neural organoids and transition them to flexible electronics manufacturing; and (2) develop photonic-based sensors to detect small...
This Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems Engineering Directorate will support $541,665 in research at The University of Iowa from October 2022 through September 2026. The grant aims to advance control of human induced pluripotent stem cell differentiation to retinal cells through genomic and microfluidic techniques. Researchers will develop genome-wide methods leveraging cell differentiation properties and biomechanics to target retinal cell endpoints. Systems biology approaches will identify master regulators of retinogenesis to validate effects of modulating differentiation pathways. Cell separation coupled with novel markers will enhance production of rod and cone photoreceptor cells. The research also supports biomanufacturing workforce development through graduate training in stem cell biology and bioengineering as well as undergraduate research opportunities. This award falls under the Engineering program (CFDA 47.041) to foster innovation in engineering research and education.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $541.7k | 8/18/22 |