Project Grant 2225300
Award Date
10/1/22
Completion Date
9/30/26
Dollars Obligated
$1M
Funding Federal Agency
Division of Molecular and Cellular Biosciences
Awarding Federal Agency
Division of Chemical, Bioengineering, Environmental, and Transport System
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
Similar Awards
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop closed-loop manufacturing processes for differentiating human pluripotent stem cells into cardiomyocytes (heart muscle cells) with improved robustness and reproducibility. The $590,283 award to the University of Wisconsin-Madison will leverage single-cell transcriptomics and epigenomics to identify key points of differentiation...
This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $600,000 to Dartmouth College aims to develop methodologies for efficiently manufacturing mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to accelerate drug development and cardiac disease modeling. The project will employ biochip design, machine learning, developmental biology, and tissue engineering approaches to enhance the structural and functional maturity of...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is supporting a collaborative research effort focused on developing an intelligent lab-on-chip device to monitor and promote the maturation of stem cell-derived cardiomyocytes. The $192,150 award to the New York Institute of Technology (NYIT) aims to create an integrated system that can non-invasively evaluate cardiomyocyte maturity in real-time and adaptively apply electrical and mechanical...
This $100,000 Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems supports the development of a 3D human stem cell cardiac model for cardiac electrophysiology medical device safety assessment. Funded under the NSF Engineering program (CFDA 47.041), this award will allow the University of Maryland, College Park to create a novel in vitro model for evaluating the safety and efficacy of cardiac medical devices through January...
The National Science Foundation (NSF) Engineering program awarded a $695,746 CAREER grant to The Washington University's Office of Sponsored Research Services Division to support research aimed at understanding how to grow more mature heart muscle from induced pluripotent stem cells (iPSCs) in the laboratory. The research project will investigate how combining mechanical loading and changes in energy sources can enhance the electrical maturation of iPSC-derived cardiomyocytes to better predict...
This four-year Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems provides $480,000 to support research titled "COLLABORATIVE RESEARCH: RECODE: DIRECTING AND CONTROLLING CARDIAC DIFFERENTIATION THROUGH CELLULAR AND MICROENVIRONMENTAL MANIPULATION AND APPLICATION OF MACHINE-LEARNING." The research is being conducted under the NSF Engineering program (CFDA 47.041) to advance engineering innovation and...
This $1,000,000 National Science Foundation project grant will fund the Reproducible Cells and Organoids via Directed-Differentiation Encoding (RECODE) project at the University of Michigan from November 1, 2022 to October 31, 2026. The project aims to employ innovative biophysical, data-driven, and synthetic gene circuit engineering methods to better understand how adult human mesenchymal stem cells transform into chondrocytes, the cells that form cartilage. Specifically, the researchers will...
This five-year, $397,457 Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) supports research into engineering autonomic control of cardiac tissues. The principal investigator will develop heterotypic multicellular models to measure the effects of autonomic innervation on cardiac contractile behavior and cellular composition. Stem cells will be differentiated into sympathetic and parasympathetic neurons and mixed with cardiomyocytes at different...
This $174,195 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies based on measuring the fluorescence lifetime of the molecule NAD(P)H, which can indicate cell metabolic activity. The primary goals are to (1) create a single-cell deposition module that can identify stem cells within mixed populations based on NAD(P)H fluorescence lifetimes, and (2) separate metabolic subpopulations within stem cell lines...
The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $467,202 project grant to the Research Foundation of the City University of New York (RFCUNY) to develop an intelligent lab-on-chip device that can non-invasively monitor the maturation of stem cell-derived cardiomyocytes in real-time and apply adaptive biophysical stimulation to promote full cell maturation. The interdisciplinary research team from RFCUNY, City College of New York, and Rutgers University plans...