This Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) aims to develop scalable manufacturing processes for engineered extracellular vesicles (EVs) that can serve as targeted drug delivery vehicles. The $2.55M grant to Vanderbilt University, awarded on January 1, 2024, will fund research to harness cellular processes for optimizing EV production, cargo loading, and cellular uptake. The long-term goal is to establish a biomanufacturing platform for...
The National Science Foundation awarded the University of Virginia a $133,333 project grant under the Engineering federal grant program (CFDA 47.041). The grant will fund a collaborative research project investigating the role of microenvironments, manufacturing processes, and metabolism on mesenchymal stromal cell production of extracellular vesicles. Specifically, the University will examine the effects of three-dimensional hydrogel microenvironments and manufacturing strategies on...
The National Science Foundation (NSF) Office of Integrative Activities awarded a $738,400 Project Grant to the Morehouse School of Medicine (MSM) to investigate the synergistic effects of engineered extracellular vesicles (EVs) from stem cells and macrophages on angiogenesis, the formation of new blood vessels. The 4-year project will explore how EVs from different cell types cooperatively regulate normal and pathological angiogenesis, as well as develop novel EV-based therapeutic strategies....
This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), provides $503,000 to Harvey Mudd College to enhance understanding of extracellular vesicle biogenesis through substrate-associated signals. The research will interrogate factors influencing extracellular vesicle formation and selective cargo packaging in astrocytes. Engineered hydrogel substrates engaging integrins expressed by...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is funding the development of a novel imaging platform for high-throughput, highly-multiplexed analysis of extracellular vesicles (EVs). The $298,999 award to Numentus Technologies Inc. aims to create a technology that can rapidly analyze up to 10 surface protein markers across 10 million individual EVs from clinical specimens like...
This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and...
The University of Georgia Research Foundation, Inc. received a $200,000 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The three-year award runs from June 2023 to May 2026 to investigate the role of microenvironment, manufacturing processes, and metabolism on mesenchymal stromal cell production of extracellular vesicles. Specifically, the University of Georgia Research...
This National Science Foundation (NSF) Project Grant under CFDA Number 47.041 - Engineering provides $360,000 in funding to Cornell University from July 1, 2023 to June 30, 2026 to develop a novel biosensing platform for the simultaneous detection and quantification of exosomes (small vesicles released from cells) and their molecular cargo. The key objectives are to: (1) develop methods to capture, quantify, and profile exosomes using a plasmonic biosensor; (2) develop techniques to lyse the...
This $250,000 National Science Foundation Technology, Innovation, and Partnerships Project Grant supports the development of artificial substrates for growing human stem cells suitable for clinical applications at Oakland University from March 2023 to February 2025. The goal is to accelerate the potential benefits of using human pluripotent stem cells and their derivatives for treating and curing diseases by producing a synthetic substrate that supports growth of human pluripotent stem cells...
This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $600,000 to Dartmouth College aims to develop methodologies for efficiently manufacturing mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to accelerate drug development and cardiac disease modeling. The project will employ biochip design, machine learning, developmental biology, and tissue engineering approaches to enhance the structural and functional maturity of...