This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks to integrate microfluidic organoid generation with automated liquid handling to minimize operator influence and enable future scaling. It will also validate predictive power by testing a range of compounds with known toxicities and examining tissue morphology, cell marker expression, and metabolism outcomes. The results will determine the platform's predictive capabilities to efficiently assess toxicological experiments. This award supports the NSF's mission to advance breakthrough technologies and solutions to national challenges through evaluation of intellectual merit and broader impacts.
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