This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Program (CFDA 93.121), provides $1,867,823.00 to Cincinnati Children's Hospital Medical Center to study the genomic and developmental mechanisms underlying Six2-related frontonasal dysplasia, a congenital craniofacial disorder. The research aims to unravel how structural variations in the genome can disrupt the local organization of...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $493,458 to support research on the role of ARID1 proteins in regulating the development and differentiation of cranial neural crest cells. The 5-year award, effective from June 16, 2025 to March 31, 2030, will be conducted by the Childrens Hospital Medical Center in Cincinnati, Ohio. The research aims to...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $619,304.36 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on mapping and predicting the effects of transcription factor dosage on craniofacial morphology and disease. The project aims to develop tools to precisely modulate the dosage of craniofacial transcription factors in...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to establish a novel zebrafish model of syndromic craniosynostosis. The $313,000 award to Emory University will enable comprehensive phenotypic, mechanistic, and genetic analyses of the craniosynostosis mutant zebrafish to better understand the underlying pathological mechanisms. The research aims to identify...
This Project Grant award, totaling $313,000.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The award will fund a secondary analysis of whole genome sequencing data from the Gabriella Miller Kid's First (GMKF) orofacial cleft cohorts to identify genetic variants located within regulatory elements active in the facial ectoderm, as well as investigate deep intronic variants in...
This Project Grant award of $804,478 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to generate a single-cell atlas of human craniofacial development and use evolutionary analysis to identify enhancers critical for midface development. The goal is to improve understanding of the genetic basis of midface defects, including clefts of the lip and palate, which can substantially...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, aims to elucidate the role of TGF-beta signaling in craniofacial fibrous dysplasia (CFD), a debilitating skeletal disease. With total funding of $306,600 awarded on September 24, 2024, the project will investigate the mechanisms driving TGF-beta signaling in response to constitutive activation of G-protein coupled receptor...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $252,752.00 to The Regents of the University of California, San Francisco to conduct research on the developmental and molecular basis of Catel-Manzke Syndrome, a craniofacial condition. The research aims to pinpoint the affected developmental processes through mouse genetic and quantitative morphometric assays,...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $600,029 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Cedars-Sinai Medical Center. The grant, which runs from March 10, 2025 to February 28, 2030, supports research to elucidate the molecular and cellular mechanisms by which Ras/MAPK signaling dysregulation causes abnormal enamel formation and craniofacial development. The research aims to determine how Ras signaling disruption...