Project Grant R03DE034548
Award Date
7/1/25
Completion Date
6/30/27
Dollars Obligated
$313K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Missouri, USA
Similar Awards
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $645,034 to the University of Pittsburgh to leverage whole genome sequencing and functional genomic characterization to improve the gene discovery process for non-syndromic cleft lip with or without cleft palate (NSCLP). The key objectives are to: (1) integrate gene- and variant-based analyses to determine the...
This Project Grant award of $804,478 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to generate a single-cell atlas of human craniofacial development and use evolutionary analysis to identify enhancers critical for midface development. The goal is to improve understanding of the genetic basis of midface defects, including clefts of the lip and palate, which can substantially...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $646,212 to support research on the role of primary cilia and C2CD3 in craniofacial skeletogenesis. The research aims to determine how mutations in the C2CD3 gene, which cause the human ciliopathy Oral-Facial-Digital Syndrome 14 (OFD14), impact skeletal differentiation, the association between the centriole and actin...
This Project Grant award, totaling $1,009,425.00, was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to investigate the impact of maternal dietary vitamin A on the risk and severity of cleft lip/palate in genetically predisposed embryos, using established mouse models. Specifically, the project will explore how maternal diet, particularly vitamin A levels, can...
This Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, will fund research into the genetic basis of human skeletal facial morphology through July 2025. Provided under the Oral Diseases and Disorders Research program (CFDA 93.121), the $936,510 in funding will support two key aims. First, the awardee will enhance current mesh landmarking procedures for craniofacial bone by developing a dense quasi-landmark...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
This National Institute of Dental and Craniofacial Research (NIDCR) Project Grant award under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $320,053 to the University of Southern California (USC) to conduct comprehensive research on the craniofacial skeleton and connective tissue development. The 8-year project will utilize advanced techniques in spatial transcriptomics and mouse genetics to identify genes and pathways regulating the assembly of the craniofacial...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $619,304.36 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on mapping and predicting the effects of transcription factor dosage on craniofacial morphology and disease. The project aims to develop tools to precisely modulate the dosage of craniofacial transcription factors in...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $606,296 project grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Missouri System on May 1, 2025. The grant supports a 5-year research project to develop state-of-the-art, three-dimensional growth models of the craniofacial complex using advanced cone-beam computed tomography (CBCT) imaging. The goal is to create new growth standards that incorporate the three-dimensional nature of the...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Program (CFDA 93.121), provides $1,867,823.00 to Cincinnati Children's Hospital Medical Center to study the genomic and developmental mechanisms underlying Six2-related frontonasal dysplasia, a congenital craniofacial disorder. The research aims to unravel how structural variations in the genome can disrupt the local organization of...