Project Grant R21DE033889

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $252,752 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to The Regents of the University of California, San Francisco (UCSF). The funding will support a study to understand the developmental and molecular functions of the TGDS gene, which is associated with Catel-Manzke Syndrome, a rare craniofacial disorder. The research team will use mouse genetic and quantitative morphometric approaches combined with transcriptomic, glycomic, and metabolomic analyses to pinpoint the affected developmental processes and elucidate the etiology of this disease. Completion of the project by January 31, 2027 is expected to provide novel insights into an unstudied gene, reveal the underlying causes of a craniofacial syndrome, and contribute to the fundamental understanding of how metabolic pathways regulate craniofacial development.